Outcome of adolescents and young adults with acute lymphoblastic leukemia in a single center in Brazil

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dc.TypeArticlept_BR
dc.contributor.authorAguiar, Thais Ferraz
dc.contributor.authorBarbosa, Thayana da Conceição
dc.contributor.authorMaciel, Ana Luiza Tardem
dc.contributor.authorBlunck, Caroline Barbieri
dc.contributor.authorLaclette, João de Sellos Rocha
dc.contributor.authorMelo, Andreia Cristina de
dc.contributor.authorMansur, Marcela Braga
dc.contributor.authorEmerenciano, Mariana
dc.date.accessioned2023-01-17T19:40:30Z
dc.date.available2023-01-17T19:40:30Z
dc.date.issued2022
dc.descriptionDOI: 10.1016/j.htct.2022.06.006pt_BR
dc.description.abstractIntroduction: Acute lymphoblastic leukemia (ALL) presents a poor prognosis in adults. The adoption of pediatric protocols has been changing this scenario, especially for adolescents and young adults (AYA). Objective and method: We aimed to evaluate a consecutive series of patients treated at the State Institute of Hematology of Rio de Janeiro between 2012 and 2020, focusing on the AYA subgroup. Result: The B-ALL was the most frequent subtype (81.6%) and AYA, the predominant age group (57.7%). The median overall survival (OS) was 9.4 months. High early mortality was observed and sepsis was the main cause of death. Better OS results were noted in AYA, in comparison to over 39y (13.3 × 6.2 months, respectively), the Berlin-Frankfurt-Münster (BFM) being the protocol of choice in this group. Conclusion: The use of the pediatric protocol seems to improve the OS of AYA, however, high rates of deaths from infection were observed, demonstrating the need for advances in the Brazilian public system clinical support.pt_BR
dc.identifier.citationAGUIAR, Thais Ferraz; BARBOSA, Thayana da Conceição; MACIEL, Ana Luiza Tardem; BLUNK, Caroline Barbieri; LACLETTE, João de Sellos Rocha; MELO, Andreia Cristina de; MANSUR, Marcela Braga; EMERENCIANO, Mariana. Outcome of adolescents and young adults with acute lymphoblastic leukemia in a single center in Brazil. Hematology, Transfusion and Cell Therapy, Rio de Janeiro, 2022. DOI: 10.1016/j.htct.2022.06.006pt_BR
dc.identifier.issn2531-1379
dc.identifier.urihttps://ninho.inca.gov.br/jspui/handle/123456789/12331
dc.language.isoengpt_BR
dc.publisherHematology, Transfusion and Cell Therapypt_BR
dc.subjectLeucemia-Linfoma Linfoblástico de Células Precursoraspt_BR
dc.subjectPrecursor Cell Lymphoblastic Leukemia-Lymphomapt_BR
dc.titleOutcome of adolescents and young adults with acute lymphoblastic leukemia in a single center in Brazilpt_BR

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