Indications of Carbapenem resistance evolution Through Heteroresistance as an intermediate stage in Acinetobacter Baumannii after carbapenem administration

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dc.TypeArticlept_BR
dc.contributor.authorSuperti, Silvana Vargas
dc.contributor.authorCaierão, Juliana
dc.contributor.authorMartins, Daniela de Souza
dc.contributor.authorSoares, Fabiana da Silva
dc.contributor.authorProchnow, Taísa
dc.contributor.authorZavascki, Alexandre Prehn
dc.date.accessioned2022-07-13T18:35:11Z
dc.date.available2022-07-13T18:35:11Z
dc.date.issued2009
dc.descriptionp. 111-113.: il. p&b.
dc.description.abstractWe describe an in vivo evolution of an antimicrobial profile from susceptibility to full-resistance to carbapenems, with heteroresistance as an intermediate stage, in an Acinetobacter baumannii strain. Heteroresistance was characterized by the growth of sub-populations within the susceptibility halo in both disk-diffusion and Etest. PCRs for the main A. baumannii carbapenemases were negative. The exact resistance mechanism, diagnostic methods and clinical relevance of heteroresistance in A. baumannii warrant further investigations. This is the first description of such phenomenon in vivo and the second report of heteroresistance to carbapenems in A. baumannii.
dc.description.abstractenDescrevemos a evolução in vivo, de um perfil de sensibilidade aos antimicrobianos, passando de sensibilidade a resistência total aos antibióticos carbapenêmicos, com um estágio intermediário de heteroresistência em isolado de Acinetobacter baumannii. A heteroresistência foi caracterizada pelo crescimento de sub-população na zona de inibição pelo método de disco-difusão e pelo Etest. PCRs para as principais carbapenemases envolvidas com resistência neste microrganismo foram negativas. O exato mecanismo de resistência envolvido, método diagnóstico e relevância clínica justificam investigação adicional. Esta é a primeira descrição deste fenômeno in vivo e o segundo relato de heteroresistência em A. baumannii.
dc.identifier.citationSUPERTI, Silvana Vargas et al. Indications of Carbapenem resistance evolution Through Heteroresistance as an intermediate stage in Acinetobacter Baumannii after carbapenem administration. Rev. Inst. Med. Trop. S. Paulo, v. 51, n. 2, p. 111-113, mar./apr. 2009.
dc.identifier.issn1678-9946
dc.identifier.urihttp://sr-vmlxaph03:8080/jspui/handle/123456789/9091
dc.publisherRev. Inst. Med. Trop. S. Paulopt_BR
dc.subjectAcinetobacter baumanniipt_BR
dc.subjectCarbapenêmicospt_BR
dc.subjectCarbapenemspt_BR
dc.subjectMeropenémpt_BR
dc.subjectMeropenempt_BR
dc.subjectCarbapenémicos
dc.titleIndications of Carbapenem resistance evolution Through Heteroresistance as an intermediate stage in Acinetobacter Baumannii after carbapenem administrationpt_BR

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