Presence of CD34+ in Megakaryocytes in Association With p53 Expression Predicts Unfavorable Prognosis in Low-risk Myelodysplastic Syndrome Patients

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dc.TypeArticlept_BR
dc.contributor.authorSantos, Talyta Ellen de Jesus dos
dc.contributor.authorDuarte, Fernando Barroso
dc.contributor.authorBarbosa, Maritza Cavalcante
dc.contributor.authorMoura, Anna Thawanny Gadelha
dc.contributor.authorVasconcelos, João Paulo Leitão de
dc.contributor.authorRocha-Filho, Francisco Dário
dc.contributor.authorCoutinho, Diego Ferreira
dc.contributor.authorVasconcelos, Paulo R. L.
dc.contributor.authorGarcia, Yhasmine Delles Oliveira
dc.contributor.authorLemes, Romélia Pinheiro Gonçalves
dc.contributor.authorRenault, Ilana Zalcberg
dc.date.accessioned2022-04-18T20:11:18Z
dc.date.available2022-04-18T20:11:18Z
dc.date.issued2019
dc.description.abstractBackground/Aim: Although risk stratification using the Prognostic Scores Systems (IPSS, WPSS and IPSSR) incorporate key information about prognosis of patients with Myelodysplastic syndromes (MDS), patients classified as low-risk may evolve rapidly and aggressively, despite a “favorable” prognostic stratification. The aim of this study was to identify biomarkers for predicting prognosis, and for better stratification and management of these patients. Materials and Methods: Expression of CD34 and p53 in megakaryocytes was examined by immunohistochemistry in 71 MDS patients classified as low-risk. Results: CD34 staining in megakaryocytes was associated with p53 expression (p=0.0166). CD34 and p53 expression were associated to worse overall survival in patients (p=0.0281). Conclusion: The presence of CD34 in megakaryocytes is associated with p53 expression and an adverse prognosis for MDS patientspt_BR
dc.identifier.issn1791-7549
dc.identifier.otherDoi: 10.21873/invivo.11472
dc.identifier.urihttp://sr-vmlxaph03:8080/jspui/handle/123456789/6510
dc.language.isoenpt_BR
dc.publisherIn vivopt_BR
dc.subjectSíndromes Mielodisplásicaspt_BR
dc.subjectMyelodysplastic Syndromespt_BR
dc.subjectAntígenos CD34pt_BR
dc.subjectAntigens, CD34pt_BR
dc.subjectMegacariócitospt_BR
dc.subjectMegakaryocytespt_BR
dc.subjectProteína Supressora de Tumor p53pt_BR
dc.subjectTumor Suppressor Protein p53pt_BR
dc.subjectPrognósticopt_BR
dc.subjectPrognosispt_BR
dc.subject.otherLow Risk
dc.titlePresence of CD34+ in Megakaryocytes in Association With p53 Expression Predicts Unfavorable Prognosis in Low-risk Myelodysplastic Syndrome Patientspt_BR

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