Synthesis and evaluation of quinonoid compounds against tumor cell lines.

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dc.TypeArticlept_BR
dc.contributor.authorSilva Júnior, Eufrânio Nunes da
dc.contributor.authorCavalcanti, Bruno Coelho
dc.contributor.authorGuimarães, Tiago Teixeira
dc.contributor.authorPinto, Maria do Carmo Freire Ribeiro
dc.contributor.authorCabral, Igor
dc.contributor.authorPessoa, Claudia do Ó
dc.contributor.authorLotufo, Leticia Veras Costa
dc.contributor.authorMoraes Filho, Manoel Odorico de
dc.contributor.authorAndrade, Carlos Kleber Zago de
dc.contributor.authorSantos, Marcelo Rodrigues dos
dc.contributor.authorSimone, Carlos Alberto de
dc.contributor.authorPinto, Antonio Ventura
dc.contributor.authorGoulart, Marilia Oliveira Fonseca
dc.date.accessioned2022-07-05T17:07:01Z
dc.date.available2022-07-05T17:07:01Z
dc.date.issued2011
dc.descriptionp. 399-410.: il. p&b.
dc.description.abstractThirty two compounds were synthesized in moderate to high yields and showed activity against cancer cells HL-60 (leukemia), MDA-MB435 (melanoma), HCT-8 (colon) and SF295 (central nervous system), with IC50 below 2 mM for some compounds. The b-lapachone-based 1,2,3-triazoles showed the best cytoxicity profile and emerge as promising anticancer prototypes. Insights about the reactive oxygen species (ROS) mechanism of anticancer action for some compounds were obtained by addition of 1-bromoheptane that deplete reduced glutathione (GSH) content and by using N-acetylcysteine that protects cells against apoptotic cellular death, as well by analysis of thiobarbituric acid reactive substances (TBARS) formation, and oxidative DNA damage after treatment detected by the comet assay with the bacterial enzymes formamidopyrimidine DNA-glycosylase (FPG) and endonuclease III (ENDOIII).
dc.identifier.citationSILVA JÚNIOR, Eufrânio Nunes da et al. Synthesis and evaluation of quinonoid compounds against tumor cell lines. European Journal of Medicinal Chemistry, v. 46, p. 399-410, 2011.
dc.identifier.urihttp://sr-vmlxaph03:8080/jspui/handle/123456789/8658
dc.publisherEuropean Journal of Medicinal Chemistrypt_BR
dc.subjectNaftoquinonaspt_BR
dc.subjectNaphthoquinonespt_BR
dc.subjectNeoplasiaspt_BR
dc.subjectNeoplasmspt_BR
dc.subjectLinhagem Celular Tumoralpt_BR
dc.subjectCell Line, Tumorpt_BR
dc.subjectCitotoxinaspt_BR
dc.subjectCytotoxinspt_BR
dc.subjectLínea Celular Tumoral
dc.titleSynthesis and evaluation of quinonoid compounds against tumor cell lines.pt_BR

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