A comparative study of 131I and 177Lu labeled somatostatin analogues for therapy of neuroendocrine tumours

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dc.TypeArticlept_BR
dc.contributor.authorAraújo, Elaine Bortoleti de
dc.contributor.authorPujatti, Priscilla Brunelli
dc.contributor.authorCaldeira Filho, Jose de Souza
dc.contributor.authorColturato, Maria Tereza
dc.contributor.authorMuramoto, Emiko
dc.contributor.authorNagamati, Lúcio Takeshi
dc.contributor.authorCouto, Renata Martinussi
dc.contributor.authorMengatti, Jair
dc.contributor.authorSilva, Christiano Pereira
dc.date.accessioned2022-07-12T12:10:37Z
dc.date.available2022-07-12T12:10:37Z
dc.date.issued2009
dc.descriptionp. 227–233.: il p&b. e color.
dc.description.abstractThis work analysed the influence of the chelating group and radioligand on somatostatin analogues in vivo and in vitro properties. The presence of DOTA in the radioiodinated peptide produced a labeled analogue with similar blood kinetics and biodistribution to 177Lu-DOTATATE and with lower abdominal uptake than 131I-TATE. In addition, 131I-DOTATATE showed significative tumour uptake, despite not so persistent after 24 h. 131I-DOTATATE can represent a cost-effective alternative to lutetium labeled peptide for neuroendocrine tumours therapy.
dc.identifier.citationARAÚJO, Elaine Bortoleti de et al. A comparative study of 131I and 177Lu labeled somatostatin analogues for therapy of neuroendocrine tumours. Applied Radiation and Isotopes, v. 67, p. 227–233, 2009.
dc.identifier.urihttp://sr-vmlxaph03:8080/jspui/handle/123456789/8931
dc.publisherApplied Radiation and Isotopespt_BR
dc.subjectSomatostatinapt_BR
dc.subjectSomatostatinpt_BR
dc.subjectTumores Neuroendócrinospt_BR
dc.subjectNeuroendocrine Tumorspt_BR
dc.subjectTumores Neuroendocrinospt_BR
dc.subjectTerapia Molecular Dirigidapt_BR
dc.subjectTerapia de Alvo Molecularpt_BR
dc.subjectMolecular Targeted Therapypt_BR
dc.titleA comparative study of 131I and 177Lu labeled somatostatin analogues for therapy of neuroendocrine tumourspt_BR

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