CD9 predicts ETV6-RUNX1 in childhood B-cell precursor acute lymphoblastic leukemia

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dc.TypeArticlept_BR
dc.contributor.authorBlunck, Caroline Barbieri
dc.contributor.authorPina, Eugênia Terra Granado
dc.contributor.authorAvila, Elda Pereira Noronha
dc.contributor.authorWajnberg, Gabriel
dc.contributor.authorPassetti, Fabio
dc.contributor.authorOliveira, Maria do Socorro Pombo de
dc.contributor.authorSá, Mariana Emerenciano Cavalcanti de
dc.date.accessioned2022-12-15T18:35:49Z
dc.date.available2022-12-15T18:35:49Z
dc.date.issued2019
dc.descriptionp. 205–211.: il. color. e p&b.
dc.description.abstractThis study aimed to re-evaluate the CD9 cellular expression by flow cytometry (FC) as a possible tool to predict the presence of ETV6-RUNX1. Method: Childhood B-cell precursor lymphoblastic leukemia cases were included (n = 186). The percentage of CD9-labeled cells and the median fluorescence intensity ratio were used for correlation with the molecular tests. Receiver Operating Characteristic curves were performed to determine the likelihood of the CD9 expression predicting ETV6-RUNX1. Results: The ETV6-RUNX1 was found in 44/186 (23.6%) cases. Data analysis revealed that the best cutoff for CD9 percentage was 64%, with an accuracy of 0.84, whereas the best cutoff for CD9 median fluorescence intensity ratio was 12.52, with an accuracy of 0.80. A strong association was observed between the level of CD9 expression and the presence of ETV6-RUNX1. Conclusion: These data confirm that the CD9 expression could be used for risk stratification in clinical practice.pt_BR
dc.identifier.citationBLUNCK, Caroline Barbieri et al. CD9 predicts ETV6-RUNX1 in childhood B-cell precursor acute lymphoblastic leucemia. Hematol Transfus Cell Ther., v. 41, n. 3, p. 205–211, 2019.
dc.identifier.issn2531-1379
dc.identifier.urihttps://ninho.inca.gov.br/jspui/handle/123456789/11727
dc.publisherHematol Transfus Cell Ther.
dc.subjectLeucemia-Linfoma Linfoblástico de Células Precursoraspt_BR
dc.subjectPrecursor Cell Lymphoblastic Leukemia-Lymphomapt_BR
dc.subjectBiomarcadorespt_BR
dc.subjectBiomarkerspt_BR
dc.subjectTetraspanina 29pt_BR
dc.subjectTetraspanin 29pt_BR
dc.subjectCitometria de Fluxopt_BR
dc.subjectFlow Cytometrypt_BR
dc.subjectETV6-RUNX 1pt_BR
dc.titleCD9 predicts ETV6-RUNX1 in childhood B-cell precursor acute lymphoblastic leukemiapt_BR

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