Cutoff values for HOMA-IR associated with metabolic syndrome in the Study of Cardiovascular Risk in Adolescents (ERICA Study)

Abstract

The aim of this study was to determine the distribution of homeostatic model assessment of insulin resistance (HOMA-IR) values and define its cutoff associated with metabolic syndrome (MetS) in the partici pants of the Study of Cardiovascular Risk in Adolescents (Estudo de Risco Cardiovascular em Adolescentes). Methods: MetS was defined according to the International Diabetes Federation criteria. HOMA-IR values were calcu lated and tabulated by corresponding percentiles for age and sex. Receiver operating characteristic curves were con structed to identify the optimal cutoff values of HOMA-IR associated with MetS in the total population and by sex. Results: We evaluated 37 815 adolescents ages 12 to 17 y. The highest HOMA-IR medians were found among girls and boys ages 12 and 14 y, respectively. Thereafter, values tended to decrease with age. The optimal cutoff values of the HOMA-IR associated with MetS in the total population, in female adolescents, and in male adolescents were 2.80, 2.32, and 2.87, respectively. Insulin resistance was prevalent in 19.1% (95% confidence interval, 17.7 20.7) of the total population, and the prevalence was higher among girls and overweight Brazilian adolescents. Conclusions: These findings may serve as new reference points for detecting insulin resistance in Brazilian adolescents.