Human Endogenous Retrovirus K in Cancer: A Potential Biomarker and Immunotherapeutic Target

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dc.TypeArticlept_BR
dc.contributor.authorCurty, Gislaine
dc.contributor.authorMarston, Jez L.
dc.contributor.authorMulder Rougvie, Miguel de
dc.contributor.authorLeal, Fabio Eudes
dc.contributor.authorNixon, Douglas F.
dc.contributor.authorSoares, Marcelo Alves
dc.date.accessioned2022-05-12T14:41:08Z
dc.date.available2022-05-12T14:41:08Z
dc.date.issued2020
dc.description.abstractIn diseases where epigenetic mechanisms are changed, such as cancer, many genes show altered gene expression and inhibited genes become activated. Human endogenous retrovirus type K (HERV-K) expression is usually inhibited in normal cells from healthy adults. In tumor cells, however, HERV-K mRNA expression has been frequently documented to increase. Importantly, HERV-K-derived proteins can act as tumor-specific antigens, a class of neoantigens, and induce immune responses in different types of cancer. In this review, we describe the function of the HERV-K HML-2 subtype in carcinogenesis as biomarkers, and their potential as targets for cancer immunotherapy.pt_BR
dc.identifier.issn1999-4915
dc.identifier.other10.3390/v12070726
dc.identifier.urihttp://sr-vmlxaph03:8080/jspui/handle/123456789/6908
dc.language.isoenpt_BR
dc.publisherVirusespt_BR
dc.subjectEndogenous Retrovirusespt_BR
dc.subjectRetrovirus Endógenospt_BR
dc.subjectHERVpt_BR
dc.subjectCarcinogenesispt_BR
dc.subjectCarcinogênesept_BR
dc.subjectCarcinogénesispt_BR
dc.subjectOncogenesispt_BR
dc.subjectOncogénesispt_BR
dc.subjectOncogênesept_BR
dc.subjectNeoplasmspt_BR
dc.subjectNeoplasiaspt_BR
dc.subjectCancerpt_BR
dc.subjectCáncerpt_BR
dc.subjectCâncerpt_BR
dc.subjectImmunitypt_BR
dc.subjectImunidadept_BR
dc.subjectInmunidadpt_BR
dc.subjectImmune Responsept_BR
dc.subjectResposta Imunept_BR
dc.subjectRespuesta Inmunept_BR
dc.subjectImmunotherapypt_BR
dc.subjectImunoterapiapt_BR
dc.subjectInmunoterapiapt_BR
dc.titleHuman Endogenous Retrovirus K in Cancer: A Potential Biomarker and Immunotherapeutic Targetpt_BR

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