Centroblastic Diffuse Large B Cell Lymphoma Displays Distinct Expression Pattern and Prognostic Role of Apoptosis Resistance Related Proteins

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dc.TypeArticlept_BR
dc.contributor.authorMendes, Gélcio Luiz Quintella
dc.contributor.authorRezende, Lidia Maria Magalhaes
dc.contributor.authorRomano, Sergio de Oliveira
dc.contributor.authorBigni, Ricardo de Sa
dc.contributor.authorFaccion, Roberta Soares
dc.contributor.authorMaia, Raquel Ciuvalschi
dc.date.accessioned2023-07-21T18:05:46Z
dc.date.available2023-07-21T18:05:46Z
dc.date.issued2012
dc.description.abstractCentroblastic diffuse large B cell lymphoma (DLBCL) samples were analyzed by immunohistochemistry to evaluate the expression of p53, Bcl-2, Survivin, XIAP, and Ki-67. Survivin was the only protein which expression exhibited a trend for impact in progression-free (p = .077) and overall survival (p = .054). In the Mann-Whitney test, Survivin expression correlated with a negative overall survival (p = .045). These results appeared to be intimately related to Survivin cytoplasmic localization. Moreover, the anti-apoptotic proteins Bcl-2 and Survivin were less frequent in centroblastic DLBCL. Our results indicate that centroblastic DLBCL may be a disease with characteristic biology and clinical course and, therefore, specific prognostic factors.pt_BR
dc.identifier.issn1532-4192
dc.identifier.urihttps://ninho.inca.gov.br/jspui/handle/123456789/14458
dc.subjectLinfoma Difuso de Grandes Células Bpt_BR
dc.subjectLymphoma Large B-Cell Diffusept_BR
dc.subjectGenes p53pt_BR
dc.subjectGenes bcl-2pt_BR
dc.subjectSurvivinapt_BR
dc.subjectSurvivinpt_BR
dc.subjectProteínas Inibidoras de Apoptose Ligadas ao Cromossomo Xpt_BR
dc.subjectX-Linked Inhibitor of Apoptosis Proteinpt_BR
dc.subjectAntígeno Ki-67pt_BR
dc.subjectKi-67 Antigenpt_BR
dc.subjectPrognósticopt_BR
dc.subjectPrognosispt_BR
dc.subjectImuno-Histoquímicapt_BR
dc.subjectImmunohistochemistrypt_BR
dc.titleCentroblastic Diffuse Large B Cell Lymphoma Displays Distinct Expression Pattern and Prognostic Role of Apoptosis Resistance Related Proteinspt_BR

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