Evaluation and comparison of a new DOTA and DTPA-bombesin agonist in vitro and in vivo in low and high GRPR expressing prostate and breast tumor models

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dc.TypeArticlept_BR
dc.contributor.authorPujatti, Priscilla Brunelli
dc.contributor.authorFoster, Julie
dc.contributor.authorFinucane, Ciara
dc.contributor.authorHudson, Chantelle
dc.contributor.authorBurnet, Jerome
dc.contributor.authorPasqualoto, Kerly Fernanda Mesquita
dc.contributor.authorMengatti, Jair
dc.contributor.authorMather, Stephen
dc.contributor.authorAraújo, Elaine Bortoleti de
dc.contributor.authorSosabowski, Jane
dc.date.accessioned2022-07-08T19:26:51Z
dc.date.available2022-07-08T19:26:51Z
dc.date.issued2015
dc.descriptionp. 91–101.: il. p&b. e color.
dc.description.abstractWe evaluated and compared a new bombesin analog [Tyr–Gly5, Nle14]-BBN(6–14) conjugated to DOTA or DTPA and radiolabeled with In-111 in low and high GRPR expressing tumor models. Both peptides were radiolabeled with high radiochemical purity and specific activity. In vitro assays on T-47D, LNCaP and PC3 cells showed that the affinity of peptides is similar and a higher binding and internalization of DOTApeptide to PC-3 cells was observed. Both peptides could target PC-3 and LNCaP tumors in vivo and both tumor types could be visualized by microSPECT/CT.
dc.identifier.citationPUJATTI, Priscilla Brunelli et al. Evaluation and comparison of a new DOTA and DTPA-bombesin agonist in vitro and in vivo in low and high GRPR expressing prostate and breast tumor models. pplied Radiation and Isotopes, v. 96, p. 91–101, 2015.
dc.identifier.urihttp://sr-vmlxaph03:8080/jspui/handle/123456789/8908
dc.publisherpplied Radiation and Isotopespt_BR
dc.subjectBombesinapt_BR
dc.subjectBombesinpt_BR
dc.subjectÁcido Pentéticopt_BR
dc.subjectPentetic Acidpt_BR
dc.subjectGRPRpt_BR
dc.subjectEstudos de Casos e Controlespt_BR
dc.subjectCase-Control Studiespt_BR
dc.subjectDOTApt_BR
dc.titleEvaluation and comparison of a new DOTA and DTPA-bombesin agonist in vitro and in vivo in low and high GRPR expressing prostate and breast tumor modelspt_BR

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