Composition of urinary glycosaminoglycans in a patient with relapsing polychondritis

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dc.TypeArticlept_BR
dc.contributor.authorDias, Claudia de Oliveira Passos
dc.contributor.authorOnofre, Glaucia Rosa
dc.contributor.authorMartins, Rita
dc.contributor.authorGraff, Daniele
dc.contributor.authorPagani, Evilmara Adélia
dc.contributor.authorSodré, Celso Tavares
dc.contributor.authorSilva, Luiz Claudio Francisco da
dc.date.accessioned2022-04-25T17:25:32Z
dc.date.available2022-04-25T17:25:32Z
dc.date.issued2002
dc.descriptionp. 377–381.: il. p&b.
dc.description.abstractObjectives: Several investigators have reported an increase in urinary glycosaminoglycans (GAGs) in patients with relapsing polychondritis (RP). The aim of this investigation is to analyze the composition and structure of urinary GAGs from a Brazilian patient with RP. Design and methods: The identification and structural analyses of the GAGs were made by electrophoresis and degradation with specific enzymes and identification of their disaccharides products by HPLC chromatography. Results: The disaccharide products formed from RP urinary chondroitin sulfate (CS) by action of chondroitin ABC lyase showed a substantial relative increase of nonsulfated disaccharides with a relative decrease of 6-sulfated disaccharides compared to control subjects. In addition, a significant change of the ratio of CS and heparan sulfate was also observed in the RP patient. Conclusion: The RP patient analyzed has shown a structural anomaly of the urinary CS and this may contribute to the diagnosis of this disease. © 2002 The Canadian Society of Clinical Chemists. All rights reserved.
dc.description.abstractSeveral investigators have reported an increase in urinary glycosaminoglycans (GAGs) in patients with relapsing polychondritis (RP). The aim of this investigation is to analyze the composition and structure of urinary GAGs from a Brazilian patient with RP. Design and methods: The identification and structural analyses of the GAGs were made by electrophoresis and degradation with specific enzymes and identification of their disaccharides products by HPLC chromatography. Results: The disaccharide products formed from RP urinary chondroitin sulfate (CS) by action of chondroitin ABC lyase showed a substantial relative increase of nonsulfated disaccharides with a relative decrease of 6-sulfated disaccharides compared to control subjects. In addition, a significant change of the ratio of CS and heparan sulfate was also observed in the RP patient. Conclusion: The RP patient analyzed has shown a structural anomaly of the urinary CS and this may contribute to the diagnosis of this disease.
dc.identifier.citationDIAS, Claudia de Oliveira Passos et al. Composition of urinary glycosaminoglycans in a patient with relapsing polychondritis. Clinical Biochemistry, v. 35, p. 377–381, 2002.
dc.identifier.issn1873-2933
dc.identifier.urihttp://sr-vmlxaph03:8080/jspui/handle/123456789/6561
dc.publisherClinical Biochemistrypt_BR
dc.subjectGlycosaminoglycanspt_BR
dc.subjectGlicosaminoglicanospt_BR
dc.subjectUrinary Tractpt_BR
dc.subjectSistema Urináriopt_BR
dc.subjectPolychondritis, Relapsingpt_BR
dc.subjectPolicondrite Recidivantept_BR
dc.subjectSistema Urinario
dc.subjectPolicondritis Recurrente
dc.titleComposition of urinary glycosaminoglycans in a patient with relapsing polychondritispt_BR

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