Coleção voltada para a inserção de artigos de periódicos desenvolvidos pela área de divisão médica, seus servidores e/ou colaboradores. https://ninho.inca.gov.br/jspui/handle/123456789/5177 2026-04-04T20:46:15Z 2026-04-04T20:46:15Z Tilli, Tatiana Martins Franco, Vanessa Ferreira Robbs, Bruno Kaufmann Wanderley, Joao Luiz Mendes Silva, Fabrício Ribeiro de Azevedo da Mello, Kivvi Duarte de Viola, Joao Paulo de Biaso Weber, Georg Franz Gimba, Etel Rodrigues Pereira https://ninho.inca.gov.br/jspui/handle/123456789/5400 2024-03-21T17:02:48Z 2011-01-01T00:00:00Z

Title: Osteopontin-c Splicing Isoform Contributes to Ovarian Cancer Progression Authors: Tilli, Tatiana Martins; Franco, Vanessa Ferreira; Robbs, Bruno Kaufmann; Wanderley, Joao Luiz Mendes; Silva, Fabrício Ribeiro de Azevedo da; Mello, Kivvi Duarte de; Viola, Joao Paulo de Biaso; Weber, Georg Franz; Gimba, Etel Rodrigues Pereira Abstract: Ovarian carcinoma is one of the most aggressive gynecological diseases and generally diagnosed at advanced stages. Osteopontin (OPN) is one of the proteins overexpressed in ovarian cancer and is involved in tumorigenesis and metastasis. Alternative splicing of OPN leads to 3 isoforms, OPNa, OPNb, and OPNc. However, the expression pattern and the roles of each of these isoforms have not been previously characterized in ovarian cancer. Herein, we have evaluated the expression profiling of OPN isoforms in ovarian tumor and nontumor samples and their putative roles in ovarian cancer biology using in vitro and in vivo functional assays. OPNa and OPNb were expressed both in tumor and nontumor ovarian samples, whereas OPNc was specifically expressed in ovarian tumor samples. The isoform OPNc significantly activated OvCar-3 cell proliferation, migration, invasion, anchorage-independent growth and tumor formation in vivo. Additionally, we have also shown that some of the OPNc-dependent protumorigenic roles are mediated by PI3K/Akt signaling pathway. OPNc stimulated immortalized ovarian epithelial IOSE cell proliferation, indicating a role for this isoform in ovarian cancer tumorigenesis. Functional assays using OPNc conditioned medium and an anti-OPNc antibody have shown that most cellular effects observed herein were promoted by the secreted OPNc. According to our data, OPNc-specific expression in ovarian tumor samples and its role on favoring different aspects of ovarian cancer progression suggest that secreted OPNc contributes to the physiopathology of ovarian cancer progression and tumorigenesis. Altogether, the data open possibilities of new therapeutic approaches for ovarian cancer that selectively down regulate OPNc, altering its properties favoring ovarian tumor progression Description: p. 280-293.: il. p&b.

2011-01-01T00:00:00Z Vaena, Marcella Martins de Vasconcelos Alves, Luiz Anastacio Almeida, Vinicius Cotta de https://ninho.inca.gov.br/jspui/handle/123456789/5323 2024-03-21T17:07:31Z 2016-01-01T00:00:00Z

Title: Transfusion medicine in medical education: an analysis of curricular grids in Brazil and a review of the current literature Authors: Vaena, Marcella Martins de Vasconcelos; Alves, Luiz Anastacio; Almeida, Vinicius Cotta de Abstract: Blood transfusions are one of the most performed medical procedures in the world. Thus, as education in transfusion medicine is vital to medical care, it should aim to promote a responsible practice with the rational use of blood by doctors. This study aims to investigate the situation of the teaching of transfusion medicine in medical schools in Brazil. Method: The websites of the 249 Brazilian medical schools in operation in June 2015 were visited and the curricula of the medical courses were investigated in respect to the presence or absence of a transfusion medicine discipline. When available, the subject grids were analyzed to verify whether a description of content regarding transfusion medicine was given within other disciplines. Results: Of the 249 medical school sites visited, information on the curriculum was obtained from 178. Of the medical schools that published their curriculum, 132 (74.1%) did not have disciplines of transfusion medicine or hematology and only seven (3.9%) had a discipline of transfusion medicine in the curricular grid. Conclusions: Education on transfusion medicine is of fundamental importance for safe and efficient transfusion practices. Deficiencies in medical knowledge of this subject have been found worldwide. The results of this study indicate a possible deficiency in teaching the basics of this specialty. Thus, additional prospective studies to assess the knowledge and practice of transfusion medicine in Brazilian medical schools are warranted, which could prompt a discussion on the importance of offering training in transfusion medicine to medical students. Description: p. 252-256.: il. color.

2016-01-01T00:00:00Z Vaena, Marcella Martins de Vasconcelos Alves, Luiz Anastacio https://ninho.inca.gov.br/jspui/handle/123456789/5322 2024-03-21T17:10:38Z 2019-01-01T00:00:00Z

Title: Assessment of the knowledge and perceptions of Brazilian medical residents on transfusion medicine Authors: Vaena, Marcella Martins de Vasconcelos; Alves, Luiz Anastacio Abstract: Medical education has a major social impact because it ultimately influences the quality and safety of the health service offered to the population. Several studies have acknowledged the relationship between medical knowledge on transfusion medicine and the proper use of this therapy. The rational use of blood has become a worldwide concern. In this context, the aim of the present study was to evaluate medical residents’ knowledge on transfusion medicine in hospitals located in Rio de Janeiro, Brazil, and their training during their medical education. Methods: One hundred and six residents from eight medical specialties of four hospitals participated. A questionnaire developed by the Biomedical Excellence for Safer Transfusion (BEST) group was applied to evaluate the participants’ medical knowledge. Another ques tionnaire was also applied to evaluate participant profiles regarding frequency oftransfusion prescriptions, self-perceived knowledge and relevance of the subject. Results: The mean number of correct answers to the questionnaire on knowledge about transfusion practices was 43.5% (range: 15–80%). A relationship between training during medical residency and the obtained result was observed (p-value = 0.0007). Most residents (73%) did not receive training in transfusion medicine during their graduation or residency and 93% would like to receive additional training. Conclusion: A clear deficit in the knowledge of transfusion medicine was verified, indicating the need for change in the teaching of this specialty. This result is similar to some developed countries Description: p. 37–43.: il. color. e p&b.

2019-01-01T00:00:00Z