https://ninho.inca.gov.br/jspui/handle/123456789/2007 Coleção de documentos de coordenadores e ex-coordenadores da área de Assistência do INCA 2026-02-03T20:37:58Z https://ninho.inca.gov.br/jspui/handle/123456789/14461 Title: Estimation of hazard rate of survival and relapse-free survival in a cohort of melanoma patients: a parametric approach Authors: Mendes, Gélcio Luiz Quintella; Koifman, Sergio 2013-01-01T00:00:00Z https://ninho.inca.gov.br/jspui/handle/123456789/14460 Title: Multi-generational SIR modeling: determination of parameters, epidemiological forecasting and age-dependent vaccination policies Authors: Campos, Eduardo Lima; Cysne, Rubens Penha; Madureira, Alexandre Loureiro; Mendes, Gélcio Luiz Quintella Abstract: We use an age-dependent SIR system of equations to model the evolution of the COVID-19. Parameters that measure the amount of interaction in different locations (home, work, school, other) are approximated from in-sample data using a random optimization scheme, and indicate changes in social distancing along the course of the pandemic. That allows the estimation of the time evolution of classical and age-dependent reproduction numbers. With those parameters we predict the disease dynamics, and compare our results with out-of-sample data from the City of Rio de Janeiro. Finally, we provide a numerical investigation regarding age-based vaccination policies, shedding some light on whether is preferable to vaccinate those at most risk (the elderly) or those who spread the disease the most (the youngest). There is no clear upshot, as the results depend on the age of those immunized, contagious parameters, vaccination schedules and efficiency. 2021-01-01T00:00:00Z https://ninho.inca.gov.br/jspui/handle/123456789/14459 Title: Socioeconomic status as a predictor of melanoma survival in a series of 1083 cases from Brazil: just a marker of health services accessibility? Authors: Mendes, Gélcio Luiz Quintella; Koifman, Sergio Abstract: Melanoma survival is determined by disease-related and patient-related factors; there is a growing body of evidence that other issues may play a role in this disease. In this study, the role of socioeconomic factors in the evolution of melanoma was evaluated. This was a retrospective study with incident cases of melanoma treated in an oncology center in Rio de Janeiro, Brazil, during the period of 1997-2004. The socioeconomic variable of choice was education (9 years or more vs. 8 years or less of school attendance). In this period, there were 1083 patients with primary melanoma of the skin, 58.1% with low school attendance. No difference was found in relation to the year of diagnosis with respect to overall survival. Five-year survival for the entire group was 67.0%. Men had worse survival [hazard ratio (HR) 1.91, 95% confidence interval (CI) 1.54-2.35]; a protective effect was found for whites (HR 0.64, 95% CI 0.49-0.84), higher educational level (HR 0.55, 95% CI 0.44-0.69), and upper limb lesions (HR 0.61, 95% CI 0.38-0.98). A higher risk of death was observed for patients with nodular melanoma (HR 1.96, 95% CI 1.49-2.58), acrolentiginous melanoma (HR 2.68, 95% CI 2.09-3.44), lesions in the soles and palms (HR 1.78, 95% CI 1.22-2.6), and increasing age (HR 1.02 for each year, 95% CI 1.01-1.02). In the multivariate analysis, after controlling for stage, age, sex, ethnicity, and clinical type, education remained a protective factor both for overall survival (HR 0.76, 95% CI 0.61-0.94) and for relapse-free survival (HR 0.76, 95% CI 0.61-0.94). In conclusion, socioeconomic status as measured by educational level represented an important factor related to melanoma clinical evolution in the cohort studied. 2013-06-01T00:00:00Z https://ninho.inca.gov.br/jspui/handle/123456789/14458 Title: Centroblastic Diffuse Large B Cell Lymphoma Displays Distinct Expression Pattern and Prognostic Role of Apoptosis Resistance Related Proteins Authors: Mendes, Gélcio Luiz Quintella; Rezende, Lidia Maria Magalhaes; Romano, Sergio de Oliveira; Bigni, Ricardo de Sa; Faccion, Roberta Soares; Maia, Raquel Ciuvalschi Abstract: Centroblastic diffuse large B cell lymphoma (DLBCL) samples were analyzed by immunohistochemistry to evaluate the expression of p53, Bcl-2, Survivin, XIAP, and Ki-67. Survivin was the only protein which expression exhibited a trend for impact in progression-free (p = .077) and overall survival (p = .054). In the Mann-Whitney test, Survivin expression correlated with a negative overall survival (p = .045). These results appeared to be intimately related to Survivin cytoplasmic localization. Moreover, the anti-apoptotic proteins Bcl-2 and Survivin were less frequent in centroblastic DLBCL. Our results indicate that centroblastic DLBCL may be a disease with characteristic biology and clinical course and, therefore, specific prognostic factors. 2012-01-01T00:00:00Z