DSpace Community: Coleção voltada para a inserção de documentos da área de Terapia Intensiva

Recuperação do paciente com câncer de pênis: a importância do apoio e acompanhamento parental como forma de cuidado

Sat, 01 Jan 2022 00:00:00 GMT

Title: Recuperação do paciente com câncer de pênis: a importância do apoio e acompanhamento parental como forma de cuidado Authors: Oliveira, Leila do Nascimento; Santos, Mauro Leonardo Salvador Caldeira dos; Soares, Raquel de Souza; Guimarães, Tuani Magalhães; Alcantara, Luciana da Silva Abstract: O câncer de pênis é um tumor raro, com maior incidência em homens com mais de 50 anos. A penectomia total ou parcial é o tratamento mais indicado. Esta cirurgia é muito complexa, e requer cuidados especializados desde o pré ao pós-operatório, seguidos de grande cuidado ou vigilância, necessitando de apoio familiar. Método: Trata-se de um estudo de revisão integrativa, recursos da prática baseada em evidências, que traz a literatura empírica ou teórica passada e uma compreensão das melhores evidências disponíveis sobre o conhecimento prático dos profissionais descritos na literatura (Broome, 2000). Tendo como objetivo a definição, estabelecer critérios de inclusão e exclusão para seleção de amostras, informações dos artigos selecionados, análise e discussão dos resultados. Para melhor orientar este estudo, foi utilizada a estratégia (PICO) para formular as questões norteadoras desta revisão integrativa da literatura, utilizando descritores em português e espanhol. O artigo é baseado em informações da literatura e faz um estudo de caso sobre a perspectiva pessoal de uma enfermeira oncológica sobre a recuperação de um paciente acometido por penectomia. Description: p. 1-10.: il. p&b.

Photobiomodulation therapy to treat neuropathic oral pain after contagion by COVID-19

Fri, 01 Jan 2021 00:00:00 GMT

Title: Photobiomodulation therapy to treat neuropathic oral pain after contagion by COVID-19 Authors: Gomes, Fernanda Cruz Gonçalves; Naurath, Christian; Azevedo, Luciane Hiramatsu; Zezell, Denise Maria Denise Maria Abstract: The purpose of this short communication is to show that although photobiomodulation in the treatment of neurophathic oral pain after COVID-19 contagion could be an option, photobiomodulation is not a new technique. PBMT was used with different protocols and pain was assessed using VAS (visual analogue scale - 0 until 10) before and after the consultation. Results: Evolution of VAS during the sessions showed a decrease in painful symptomatology as treatment was performed. Conclusion: Based on the results obtained in the present case report, we concluded that PBMT with the parameters used in this clinical case was an effective, noninvasive and a new option of treatment for neuralgia resulting from COVID-19 Description: p. 1-5.: il. color.

Exome-Wide Search for Genes Associated With Central Nervous System Inflammatory Demyelinating Diseases Following CHIKV Infection: The Tip of the Iceberg

Fri, 01 Jan 2021 00:00:00 GMT

Title: Exome-Wide Search for Genes Associated With Central Nervous System Inflammatory Demyelinating Diseases Following CHIKV Infection: The Tip of the Iceberg Authors: Leon, Soniza Vieira Alves; Ferreira, Cristina dos Santos; Herlinger, Alice Laschuk; Francisco Júnior, Ronaldo da Silva; Gonçalves, João Paulo da Costa; Araújo, Amanda Dutra de; Rêgo, Cláudia Cecília da Silva; Dantas, Fabricia Lima Fontes; Lopes, Fernanda Cristina Rueda; Higa, Luiza Mendonça; Gerber, Alexandra Lehmkuhl; Guimarães, Ana Paula de Campos; Menezes, Mariane Talon de; Tôrres, Marcelo Calado de Paula; Maia, Richard Araújo; Nogueira, Bruno Miceli Gonzalez; França, Laise Carolina; Silva, Marcos Martins da; Naurath, Christian; Correia, Aline Saraiva da Silva; Vasconcelos, Cláudia Cristina Ferreira; Tanuri, Amilcar; Ferreira Júnior, Orlando da Costa; Cardoso, Cynthia Chester; Aguiar, Renato Santana; Vasconcelos, Ana Tereza Ribeiro de Abstract: Chikungunya virus (CHIKV) is a re-emergent arbovirus that causes a disease characterized primarily by fever, rash and severe persistent polyarthralgia, although <1% of cases develop severe neurological manifestations such as inflammatory demyelinating diseases (IDD) of the central nervous system (CNS) like acute disseminated encephalomyelitis (ADEM) and extensive transverse myelitis. Genetic factors associated with host response and disease severity are still poorly understood. In this study, we performed whole-exome sequencing (WES) to identify HLA alleles, genes and cellular pathways associated with CNS IDD clinical phenotype outcomes following CHIKV infection. The cohort includes 345 patients of which 160 were confirmed for CHIKV. Six cases presented neurological manifestation mimetizing CNS IDD. WES data analysis was performed for 12 patients, including the CNS IDD cases and 6 CHIKV patients without any neurological manifestation. We identified 29 candidate genes harboring rare, pathogenic, or probably pathogenic variants in all exomes analyzed. HLA alleles were also determined and patients who developed CNS IDD shared a common signature with diseases such as Multiple sclerosis (MS) and Neuromyelitis Optica Spectrum Disorders (NMOSD). When these genes were included in Gene Ontology analyses, pathways associated with CNS IDD syndromes were retrieved, suggesting that CHIKV-induced CNS outcomes may share a genetic background with other neurological disorders. To our knowledge, this study was the first genome-wide investigation of genetic risk factors for CNS phenotypes in CHIKV infection. Our data suggest that HLA-DRB1 alleles associated with demyelinating diseases may also confer risk of CNS IDD outcomes in patients with CHIKV infection. Description: p. 1-13.: il. color. e p&b.

Chikungunya virus infection in a patient with Myasthenia gravis: A case report of lethal meningoencephalitis associated with high viral load.

Sat, 01 Jan 2022 00:00:00 GMT

Title: Chikungunya virus infection in a patient with Myasthenia gravis: A case report of lethal meningoencephalitis associated with high viral load. Authors: Uruçu, Lorena Martel; Albuquerque, André Gustavo Neves de; Naurath, Christian; Carreira, Márcia Nogueira; Garrido, Marianne Monteiro; Emmel, Vanessa Erichsen; Gama, Bianca Ervatti; Binato, Renata; Hassan, Rocio; Martins, Ianick Souto Abstract: Chikungunya virus (CHIKV) is a reemerging arbovirus. Besides its classical acute symptoms, rare complications such as myocarditis, hepatitis, Guillain-Barré syndrome, encephalitis and meningoencephalitis are being increasingly reported worldwide Case presentation: In the present study, we report a case of lethal encephalitis caused by CHIKV associated with high viral load in an immunosuppressed patient Case report: A 45-year-old woman with medical history of Myasthenia gravis had onset of fever (Day 1), fol lowed by skin rash and polyarthralgia of large joints. Headache and lethargy started on Day 4. On Day 7, she was hospitalized, and four days later she developed neurological deterioration, being transferred to the Intensive Care Unit. Analysis of cerebrospinal fluid (CSF) suggested viral meningoencephalitis. The first CT-scan showed no significant findings, but real time quantitative PCR was positive for CHIKV in CSF with high viral load. About 24 h after the first CT-scan, brain edema was evident on the second CT-scan. On Day 26, the patient presented progressive deterioration of brain activity and died. Few other cases of patients presenting neurological compli cations associated with CHIKV were reported in Brazil already, including a patient with Myasthenia gravis and myelitis due to CHIKV Conclusions: These cases suggest such autoimmune disorder may favor CHIKV invasion of nervous system. The present case points out the potential relation of immunosuppressive conditions and severe neurological disease caused by CHIKV infection. Description: p. 1-3.: il. p&b.