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DC Field | Value | Language |
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dc.contributor.author | Noronha, Elda Pereira | - |
dc.contributor.author | Andrade, Francianne Gomes | - |
dc.contributor.author | Andrade, Camilla Fernanda Costa Gomes de | - |
dc.contributor.author | Pina, Eugênia Terra Granado | - |
dc.contributor.author | Oliveira, Maria do Socorro Pombo de | - |
dc.contributor.author | Zampier, Carolina da Paz | - |
dc.date.accessioned | 2022-12-16T18:00:55Z | - |
dc.date.available | 2022-12-16T18:00:55Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | NORONHA, Elda Pereira et al. Immunophenotyping with CD135 and CD117 predicts the FLT3, IL-7R and TLX3 gene mutations in childhood T-cell acute leucemia. Blood Cells, Molecules and Diseases, v. 57, p. 74–80, 2016. | - |
dc.identifier.issn | 1096-0961 | - |
dc.identifier.uri | https://ninho.inca.gov.br/jspui/handle/123456789/11766 | - |
dc.description | p. 74–80.: il. p&b. | - |
dc.description.abstract | With the combination of immunophenotyping and molecular tests, it is still a challenge to identify the character istics of T cell acute lymphoblastic leukemia (T-ALL) associated with distinct outcomes. This study tests the pos sible correlation of cellular expression of CD135 and CD117 with somatic gene mutations in T-ALL. One hundred sixty-two samples were tested, including 143 at diagnosis, 15 from T-lymphoblastic lymphoma at relapse, and four relapse samples from sequential follow-up of T-ALL. CD135 and CD117 monoclonal antibodies were includ ed in the T-ALL panel of flow cytometry. The percentage of cells positivity and the median fluorescence intensity were correlated with gene mutational status. STIL-TAL1, TLX3, FLT3 and IL7R mutations were tested using stan dard techniques. STIL-TAL1 was found in 24.8%, TLX3 in 12%, IL7R in 10% and FLT3-ITD in 5% of cases. FLT3 and IL7R mutations were mutually exclusive, as were FLT3-ITD and STIL-TAL1. Associations of CD135high (p b 0.01), CD117intermediate/high (p = 0.02) and FLT3-ITD, CD117low with IL7Rmutated (p b 0.01) and CD135high with TLX3pos were observed. We conclude that the addition of CD135 and CD117 to the diagnosis can predict molecular aberrations in T-ALL settings, mainly segregating patients with FLT3-ITD, who would benefit from treatment with inhibitors of tyrosine. | pt_BR |
dc.publisher | Blood Cells, Molecules and Diseases | - |
dc.subject | Leucemia-Linfoma Linfoblástico de Células T Precursoras | pt_BR |
dc.subject | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | pt_BR |
dc.subject | Leucemia Mieloide Aguda | pt_BR |
dc.subject | Leukemia Myeloid Acute | pt_BR |
dc.subject | Proteínas Proto-Oncogênicas c-kit | pt_BR |
dc.subject | Proto-Oncogene Proteins c-kit | pt_BR |
dc.subject | Tirosina Quinase 3 Semelhante a fms | pt_BR |
dc.subject | fms-Like Tyrosine Kinase 3 | pt_BR |
dc.subject | Receptores de Interleucina-7 | pt_BR |
dc.subject | Receptors Interleukin-7 | pt_BR |
dc.title | Immunophenotyping with CD135 and CD117 predicts the FLT3, IL-7R and TLX3 gene mutations in childhood T-cell acute leukemia | pt_BR |
dc.Type | Article | pt_BR |
Appears in Collections: | Artigos de Periódicos da área de Pediatria |
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Immunophenotyping with CD135 and CD117 predicts the FLT3, IL-7R and TLX3 gene mutations in childhood T-cell acute leukemia..pdf | 702.5 kB | Adobe PDF | View/Open |
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