Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/11791
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dc.contributor.authorVasconcelos, Gisele Moledo de-
dc.contributor.authorSilva, Fernanda Azevedo-
dc.contributor.authorThuler, Luiz Claudio Santos-
dc.contributor.authorPina, Eugênia Terra Granado-
dc.contributor.authorSouza, Celeste da Silva Freitas de-
dc.contributor.authorCalabrese, Katia-
dc.contributor.authorOliveira, Maria do Socorro Pombo de-
dc.date.accessioned2022-12-19T13:25:53Z-
dc.date.available2022-12-19T13:25:53Z-
dc.date.issued2014-
dc.identifier.citationVASCONCELOS, Gisele Moledo de et al. The concurrent occurrence of Leishmania chagasi infection and childhood acute leukemia in Brazil. Revista Brasileira de Hematologia e Hemoterapia, v. 36, n. 5, p. 356–362, 2014.-
dc.identifier.issn1516-8484-
dc.identifier.urihttps://ninho.inca.gov.br/jspui/handle/123456789/11791-
dc.descriptionp. 356–362.: tab. p&b.-
dc.description.abstractThis study investigated the co-existence of Leishmania chagasi infection and childhood leukemia in patients naïve to treatment; this has serious clinical and epidemiological implications. Methods The seroprevalence of L. chagasi antibodies prior to any treatment was investigated in children with clinical features of acute leukemia. Serological tests were performed in 470 samples drawn from under 14-year-old children from different regions of Brazil with clinical suspicion of acute leukemia. Acute leukemia subtypes were characterized by immunophenotyping using flow cytometry. Morphological analyses of bone marrow aspirates were systematically performed to visualize blast cells and/or the formation of L. chagasi amastigotes. Data analysis used a standard univariate procedure and the Pearson's chi-square test. Results The plasma of 437 children (93%) displayed antibodies against L. chagasi by indirect immunofluorescence assay and enzyme-linked immunosorbent assay tests. Of the 437 patients diagnosed from 2002 to 2006, 254 had acute lymphoblastic leukemia, 92 had acute myeloid leukemia, and 91 did not have acute leukemia. The seroprevalence of L. chagasi antibodies according to the indirect immunofluorescence assay test (22.5%) was similar in children with or without acute leukemia (p-value = 0.76). The co-existence of visceral leishmanasis and acute leukemia was confirmed in 24 children. The overall survival of these children was poor with a high death rate during the first year of leukemia treatment. Conclusion In the differential diagnosis of childhood leukemia, visceral leishmanasis should be considered as a potential concurrent disease in regions where L. chagasi is endemic.pt_BR
dc.publisherRevista Brasileira de Hematologia e Hemoterapia-
dc.subjectLeishmaniose Visceralpt_BR
dc.subjectLeishmaniasis Visceralpt_BR
dc.subjectBrasilpt_BR
dc.subjectBrazilpt_BR
dc.subjectLeucemia Linfoidept_BR
dc.subjectLeukemia Lymphoidpt_BR
dc.subjectLeucemia Mieloidept_BR
dc.subjectLeukemia Myeloidpt_BR
dc.titleThe concurrent occurrence of Leishmania chagasi infection and childhood acute leukemia in Brazilpt_BR
dc.TypeArticlept_BR
Appears in Collections:Artigos de Periódicos da área de Pediatria



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