Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/12398
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dc.contributor.authorMota, Tales Henrique Andrade da-
dc.contributor.authorGuimarães, Ana Flavia Reis-
dc.contributor.authorCarvalho, Amandda Evelin Silva de-
dc.contributor.authorAraújo, Felipe Saldanha de-
dc.contributor.authorLopes, Giselle Pinto de Faria-
dc.contributor.authorPittella-Silva, Fabio-
dc.contributor.authorRabello, Doralina do Amaral-
dc.contributor.authorOliveira, Diego Madureira de-
dc.date.accessioned2023-01-19T20:51:41Z-
dc.date.available2023-01-19T20:51:41Z-
dc.date.issued2021-
dc.identifier.citationMOTA, Tales Henrique Andrade da; GUIMARÃES, Ana Flavia Reis; CARVALHO, Amandda Evelin Silva de; ARAÚJO, Felipe Saldanha de; PITTELLA-SILVA, Fabio; RABELLO, Doralina do Amaral. Effects of in vitro short- and long-term treatment with telomerase inhibitor in U-251 glioma cells. Tumor Biology, v. 43, n. 1, p. 327-340, 2021. DOI: 10.3233/TUB-211515.pt_BR
dc.identifier.issn1423-0380-
dc.identifier.urihttps://ninho.inca.gov.br/jspui/handle/123456789/12398-
dc.descriptionv. 43, n. 1, p. 327-340, 2021 DOI: 10.3233/TUB-211515pt_BR
dc.description.abstractBACKGROUND: The inhibition of the enzyme telomerase (TERT) has been widely investigated as a new pharmacological approach for cancer treatment, but its real potential and the biochemical consequences are not totally understood. OBJECTIVE: Here, we investigated the effects of the telomerase inhibitor MST-312 on a human glioma cell line after both short- and long-term (290 days) treatments. METHODS: Effects on cell growth, viability, cell cycle, morphology, cell death and genes expression were assessed. RESULTS: We found that short-term treatment promoted cell cycle arrest followed by apoptosis. Importantly, cells with telomerase knock-down revealed that the toxic effects of MST-312 are partially TERT dependent. In contrast, although the long-term treatment decreased cell proliferation at first, it also caused adaptations potentially related to treatment resistance and tumor aggressiveness after long time of exposition. CONCLUSIONS: Despite the short-term effects of telomerase inhibition not being due to telomere erosion, they are at least partially related to the enzyme inhibition, which may represent an important strategy to pave the way for tumor growth control, especially through modulation of the non-canonical functions of telomerase. On the other hand, long-term exposure to the inhibitor had the potential to induce cell adaptations with possible negative clinical implications.pt_BR
dc.language.isoengpt_BR
dc.publisherTumor Biologypt_BR
dc.relation.ispartofseriesv. 43;n. 1-
dc.subjectGliomapt_BR
dc.subjectTelomerasept_BR
dc.subjectTerapêuticapt_BR
dc.subjectTherapeuticspt_BR
dc.subjectTerapéuticapt_BR
dc.titleEffects of in vitro short- and long-term treatment with telomerase inhibitor in U-251 glioma cellspt_BR
dc.TypeArticlept_BR
dc.contributor.affilliationLaboratório Multidisciplinar de Saúde Humana, Universidade de Brasília, Ceilândia, DF, Brasil.pt_BR
dc.contributor.affilliationLaboratório de Patologia Molecular do Câncer, Universidade de Brasília, Brasília, DF, Brasil.pt_BR
dc.contributor.affilliationLaboratório de Farmacologia Molecular, Departamento de Ciências Farmacêuticas, Universidade de Brasília, Brasília, DF, Brasil.pt_BR
dc.contributor.affilliationLaboratório de Hematologia, Departamento de Ciências Farmacêuticas, Universidade de Brasília, Brasília, DF, Brasil.pt_BR
dc.contributor.affilliationLaboratório de Hemato-oncologia Celular e Molecular, Instituto Nacional do Câncer (INCA), Rio de Janeiro, RJ, Brasil.pt_BR
dc.contributor.affilliationDepartamento de Biotecnologia Marinha, Instituto de Estudos do Mar Almirante Paulo Moreira, IEAPM, Arraial do Cabo, RJ, Brasil.pt_BR
Appears in Collections:Artigo de Periódicos da Pesquisa Clínica



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