Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/13866
Title: Age-related changes in natural killer cell receptors from childhood through old age
Authors: Oliveira, Aline Almeida
Carvalho, Monique Smith
Pôrto, Luís Cristóvão de Moraes Sobrino
Oliveira, Juliana Cardoso
Ribeiro, Aline dos Santos
Falcão, Rosângela Rosa
Abdelhay, Eliana Saul Furquim Werneck
Bouzas, Luis Fernando da Silva
Thuler, Luiz Claudio Santos
Souza, Maria Helena Ornellas de
Diamond, Hilda Rachel
Keywords: Envelhecimento
Aging
Células Matadoras Naturais
Killer Cells Natural
Receptores KIR2DL2
Receptors KIR2DL2
Receptores de Células Matadoras Naturais
Receptors Natural Killer Cell
Subfamília K de Receptores Semelhantes a Lectina de Células NK
NK Cell Lectin-Like Receptor Subfamily K
Issue Date: Apr-2011
Abstract: Most studies on natural killer (NK) cells and aging have focused on overall cell numbers and global cytotoxic activity. NK cell functions are controlled by surface receptors belonging to three major families: killer cell immunoglobulin-like receptors (KIRs), natural cytotoxicity receptors (NCRs), and C-type lectins. The expres sion of these receptors was investigated from childhood through old age in T, NKT- and NK cells and also in the CD56dim (cytotoxic) and CD56bright (responsible for cytokine production) NK cell subsets. A decrease in the expression of activating receptors (NKp30 and NKp46) was observed in NK cells in elderly individuals. KIR expression was increased only in the CD56bright subset. Children presented similar results regarding expres sion of NKp30 and KIR, but not NKp46. NKG2D expression was decreased in T cells of elderly subjects. Analysis of KIR genotype revealed that KIR2DL5 and KIR2DS3 were significantly associated with old age. Cytotoxic activity was preserved from childhood through old age, suggesting that the increase of the absolute number of CD56dim, observed in elderly, may represent a compensatory mechanism for the receptor expression alterations. This initial study provides the framework for more focused studies of this subject, which are necessary to determine whether the changing balance of NK receptor expression may influence susceptibility to infectious, inflammatory, and neoplastic diseases.
URI: https://ninho.inca.gov.br/jspui/handle/123456789/13866
ISSN: 1879-1166
Appears in Collections:Hospital do Câncer I (HCI)



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