Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/13944
Title: Serum ferritin as risk factor for sinusoidal obstruction syndrome of the liver in patients undergoing hematopoietic stem cell transplantation
Authors: Maradei, Simone Cunha
Maiolino, Angelo
Azevedo, Alexandre Mello de
Colares, Marta
Bouzas, Luis Fernando da Silva
Nucci, Marcio Luiz Moore
Keywords: Ferritinas
Ferritins
Soro
Serum
Fatores de Risco
Risk Factors
Síndrome
Syndrome
Transplante de Células-Tronco Hematopoéticas
Hematopoietic Stem Cell Transplantation
Fígado
Liver
Issue Date: Aug-2009
Abstract: Hepatic sinusoidal obstruction syndrome (SOS) is a serious complication in hematopoietic stem cell transplant (HSCT) recipients. To determine the impact of pretransplantation hyperferritinemia on the risk of SOS after HSC transplantation, we retrospectively studied 427 HSCT recipients (179 autologous and 248 allogeneic). Serum ferritin levels were measured before transplantation. Patients with and without a diagnosis of SOS were compared regarding demographics; underlying disease; transplant characteristics; receipt of imatinib, busulfan, total body irradiation, gemtuzumab, vancomycin, acyclovir, or methotrexate; and baseline serum ferritin. Univariate and multivariate (stepwise logistic regression) analyses were performed. SOS was diagnosed in 88 patients (21%) at a median of 10 days (range, 2-29 days) after transplantation. By multivariate analysis, allogeneic HSC transplantation (odds ratio [OR] = 8.25; 95% confidence interval [95% CI], 3.31-20.57), receipt of imatinib (OR = 2.60; 95% CI, 1.16-5.84), receipt of busulfan (OR = 2.18; 95% CI, 1.25-3.80), and ferritin serum level higher than 1000 ng/dL (OR = 1.78; 95% CI, 1.02-3.08) were risk factors for SOS. A ferritin serum level higher than 1000 ng/dL in the pretransplantation period is an independent risk factor for SOS. The results suggest the need for prospective studies addressing the use of iron chelation in the pretransplantation period.
URI: https://ninho.inca.gov.br/jspui/handle/123456789/13944
ISSN: 1528-0020
Appears in Collections:Hospital do Câncer I (HCI)



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