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Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/14450
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dc.contributor.authorMonteiro, Andreia Salarini-
dc.contributor.authorAraújo, Sérgio Ricardo de Carvalho-
dc.contributor.authorAraujo, Luiz Henrique-
dc.contributor.authorSouza, Mirian Carvalho de-
dc.date.accessioned2023-07-20T13:43:55Z-
dc.date.available2023-07-20T13:43:55Z-
dc.date.issued2022-
dc.identifier.citationMONTEIRO, Andreia Salarini. et. al. Impact of microvascular invasion on 5-year overall survival of resected non-small cell lung cancer. Jornal Brasileiro de Pneumologia, v. 48, Issue 3, e20210283, 8 jul. 2022. ISSN 1806-3756. DOI: 10.36416/1806-3756/e20210283.pt_BR
dc.identifier.issn1806-3756-
dc.identifier.urihttps://ninho.inca.gov.br/jspui/handle/123456789/14450-
dc.description7 p. : il. color e p&b.pt_BR
dc.language.isoengpt_BR
dc.publisherJornal Brasileiro de Pneumologiapt_BR
dc.subjectCarcinoma Pulmonar de Células não Pequenaspt_BR
dc.subjectCarcinoma, Non-Small-Cell Lungpt_BR
dc.subjectarcinoma de Pulmón de Células no Pequeñaspt_BR
dc.subjectCirurgia Torácicapt_BR
dc.subjectThoracic Surgerypt_BR
dc.subjectCirugía Torácicapt_BR
dc.subjectAnálise de Sobrevidapt_BR
dc.subjectSurvival Analysispt_BR
dc.subjectAnálisis de Supervivenciapt_BR
dc.titleImpact of microvascular invasion on 5-year overall survival of resected non-small cell lung cancerpt_BR
dc.TypeArticlept_BR
dc.terms.abstractObjectives: Non-small cell lung cancer (NSCLC) is an incidental and aggressive type of cancer. Although curative treatment can be offered, the recurrence rate is relatively high. Identifying factors that have a prognostic impact may guide changes in the staging system and recommendations for adjuvant therapy. The aim of this study was to evaluate the impact of microvascular invasion on the 5-year overall survival (OS) of patients with resected NSCLC treated at a reference cancer center. Methods: This retrospective, observational cohort study included patients diagnosed with early-stage NSCLC (clinical stages I-IIIA), treated with curative-intent surgery at the Brazilian National Cancer Institute between 2010 and 2016. Results: The dataset comprised 91 surgical patients, mostly females and white, with a mean age of 62 years (range between 29-83). Cases were distributed as stages I, II, and III in 55%, 29%, and 16%. Adenocarcinoma was the predominant histological subtype (67%), and microvascular invasion was present in 25% of the patients. The 5-year OS probability was 60% (95% CI, 48.3-68.9). Among all characteristics, advanced stages (p = 0.001) and the presence of microvascular invasion (p< 0.001) were related to a worse 5-year OS. After adjusting for age group and pathological stage, the presence of microvascular invasion was associated with a 4-fold increased risk of death (HR 3.9, 95% CI, 1.9-8.2). Conclusion: The presence of microvascular invasion was an independent factor related to worse survival and, therefore, should be routinely assessed in resected specimens.pt_BR
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