Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/14522
Title: Determinants of salivary cotinine level: a population based study in Brazi
Other Titles: Determinantes dos níveis de cotinina salivar: um estudo de base populacional no Brasil
Authors: Figueiredo, Valeska Carvalho
Szklo, Moyses
Szklo, André Salem
Benowitz, Neal
Lozana, José Azevedo
Costa, Leticia Casado
Masson, Elaine
Samet, Jonathan
Keywords: Fumar
Smoking
Cotinina
Cotinine
Farmacocinética
Pharmacokinetics
Estudos Transversais
Cross Sectional Studies
Issue Date: Dec-2007
Publisher: Revista de Saúde Pública
Abstract: A cross-sectional population-based study was conducted to assess, in active smokers, the relationship of number of cigarettes smoked and other characteristics to salivary cotinine concentrations. METHODS: A random sample of active smokers aged 15 years or older was selected using a stepwise cluster sample strategy, in the year 2000 in Rio de Janeiro, Brazil. The study included 401 subjects. Salivary cotinine concentration was determined using gas chromatography with nitrogen-phosphorus detection. A standard questionnaire was used to collect demographic and smoking behavioral data. The relation between the number of cigarettes smoked in the last 24h and cotinine level was examined by means of a nonparametric fi tting technique of robust locally weighted regression. RESULTS: Signifi cantly (p<0.05) higher adjusted mean cotinine levels were found in subjects smoking their fi rst cigarette within fi ve minutes after waking up, and in those smoking 1–20 cigarettes in the last 24h who reported inhaling more than ½ the time. In those smoking 1–20 cigarettes, the slope was signifi cantly higher for those subjects waiting for more than fi ve minutes before smoking their fi rst cigarette after waking up, and those smoking “light” cigarettes when compared with their counterparts. These heterogeneities became negligible and non-signifi cant when subjects with cotinine >40 ng/mL per cigarette were excluded. CONCLUSIONS: There was found a positive association between self reporting smoking fi ve minutes after waking up, and inhaling more than ½ the time are consistent and higher cotinine levels. These can be markers of dependence and higher nicotine intake. Salivary cotinine proved to be a useful biomarker of recent smoking and can be used in epidemiological studies and smoking cessation programs.
URI: https://ninho.inca.gov.br/jspui/handle/123456789/14522
ISSN: 1518-8787
Appears in Collections:Artigos de Periódicos da área de Pesquisa Populacional



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