Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/2248
Title: Comparison of the performance of four staging systems in determining the prognosis of breast cancer among women undergoing neoadjuvant chemotherapy
Authors: Bello, Marcelo Adeodato
Keywords: Terapia Neoadjuvante
Neoadjuvant chemotherapy
Prognosis
Neoplasias da Mama
Prognóstico
Issue Date: 23-Dec-2020
Publisher: Breast Cancer
Abstract: Abstract Purpose Different tumor-related factors have been proposed to assess the risk of disease progression and death in women undergoing neoadjuvant breast cancer chemotherapy. Recently, besides the classical pre-treatment clinical stage (CS) and post-treatment pathologic stage (PS), estrogen receptor status and histologic grade (CPS + EG score) and HER2 results (Neo-Bioscore) have also been added to this suite of staging systems, generating new scores. The present study aims to compare the performance of these four staging systems, namely CS, PS, CPS + EG and Neo-Bioscore, in the prognosis of breast cancer in women undergoing neoadjuvant chemotherapy. Methods This study comprises a retrospective cohort study of female breast cancer patients diagnosed at the Brazilian National Cancer Institute, Brazil from January 2013 to December 2015. A descriptive analysis of patient characteristics was conducted, and Kaplan–Meier curves, a Cox proportional hazard analysis and Receiver Operating Characteristic (ROC) curves were developed according to the assessed staging system scores. Results A total of 803 patients were eligible for this study. Most were under 65 years old (88.0%), presented advanced tumors (clinical stage ≥ IIB 77.1%), with positive estrogen receptor (71.2%) and negative HER2 (75.7%) results. During the follow-up, 172 patients (21.4%) evolved to death. A statistical difference (p < 0.001) was observed between 5 year diseasefree survival and 5 year overall survival rates according to the PS, CPS + EG and Neo-Bioscore staging systems. Conclusion The PS, CPS + EG and Neo-Bioscore staging systems were proven to be equivalent to predict the prognosis of patients undergoing neoadjuvant chemotherapy.
URI: http://sr-vmlxaph03:8080/jspui/handle/123456789/2248
Appears in Collections:Hospital do Câncer III (HCIII)

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