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DC Field | Value | Language |
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dc.contributor.author | Melo, Andreia Cristina de | - |
dc.contributor.author | Silva, Jesse Lopes da | - |
dc.contributor.author | Santos, Alexssandra Lima Siqueira dos | - |
dc.contributor.author | Nunes, Natalia Cristina Cardoso | - |
dc.contributor.author | Silva, Flora de Moraes Lino da | - |
dc.contributor.author | Ferreira, Carlos Gil Moreira | - |
dc.date.accessioned | 2021-12-15T14:11:17Z | - |
dc.date.available | 2021-12-15T14:11:17Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | MELO, Andreia Cristina de et al. Cancer immunotherapy: the art of targeting the tumor immune microenvironment. Cancer Chemotherapy and Pharmacology, v. 84, p. 227–240, 2019. | - |
dc.identifier.issn | 1432-0843 | - |
dc.identifier.uri | http://sr-vmlxaph03:8080/jspui/handle/123456789/4789 | - |
dc.description | p. 227–240.: tab. p&b. | - |
dc.description.abstract | For many decades, cancer treatment has been strongly directed toward the development of cytotoxic and cytostatic drugs, quite often leading to disappointing results due to the inter- and intra-tumoral heterogeneity. Lately, this intra-cellular look has given way to the understanding of the tumor microenvironment, thus enabling modifcation of the immunological dynam ics between tumor cells and their host. An era of new drugs aiming to unlock the host immune system against tumor cells is steadily increasing. Strategies involving adoptive cell therapy, therapeutic vaccines, immune checkpoint inhibitors and so on have provided spectacular clinical responses and increased survival in previously refractory settings and “hard-to-treat” cancers. Based on a comprehensive search in the main scientifc databases, annals of recent renowned oncology congresses and platforms of ongoing trials, the clinical pharmacology characteristics of the main classes of immunotherapeutic agents, as well as the new treatment strategies related to immunotherapy in solid tumors, are carefully discussed throughout this review. | - |
dc.publisher | Cancer Chemotherapy and Pharmacology | pt_BR |
dc.subject | Imunoterapia | pt_BR |
dc.subject | Immunotherapy | pt_BR |
dc.subject | Microambiente Tumoral | pt_BR |
dc.subject | Tumor Microenvironment | pt_BR |
dc.subject | Sistema Imunitário | pt_BR |
dc.subject | Immune System | pt_BR |
dc.subject | Neoplasias | pt_BR |
dc.subject | Neoplasms | pt_BR |
dc.title | Cancer immunotherapy: the art of targeting the tumor immune microenvironment | pt_BR |
dc.Type | Article | pt_BR |
Appears in Collections: | Artigos de Periódicos da área de Ginecologia |
Files in This Item:
File | Description | Size | Format | |
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Cancer immunotherapy the art of targeting the tumor immune microenvironment.pdf | 873 kB | Adobe PDF | View/Open |
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