Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/4820
Title: Cancer immunotherapy: the art of targeting the tumor immune microenvironment.
Authors: Melo, Andreia Cristina de
Silva, Jesse Lopes da
Santos, Alexssandra Lima Siqueira dos
Nunes, Natalia Cristina Cardoso
Silva, Flora de Moraes Lino da
Ferreira, Carlos Gil Moreira
Keywords: Imunoterapia
Immunotherapy
Sistema Imunitário
Immune System
Microambiente Tumoral
Tumor Microenvironment
Imunoterapia Adotiva
Immunotherapy, Adoptive
Issue Date: 2019
Publisher: Cancer Chemotherapy and Pharmacology
Citation: MELO, Andreia Cristina de et al. Cancer immunotherapy: the art of targeting the tumor immune microenvironment. Cancer Chemotherapy and Pharmacology, v. 84, p. 227–240, 2019.
Abstract: For many decades, cancer treatment has been strongly directed toward the development of cytotoxic and cytostatic drugs, quite often leading to disappointing results due to the inter- and intra-tumoral heterogeneity. Lately, this intra-cellular look has given way to the understanding of the tumor microenvironment, thus enabling modifcation of the immunological dynam ics between tumor cells and their host. An era of new drugs aiming to unlock the host immune system against tumor cells is steadily increasing. Strategies involving adoptive cell therapy, therapeutic vaccines, immune checkpoint inhibitors and so on have provided spectacular clinical responses and increased survival in previously refractory settings and “hard-to-treat” cancers. Based on a comprehensive search in the main scientifc databases, annals of recent renowned oncology congresses and platforms of ongoing trials, the clinical pharmacology characteristics of the main classes of immunotherapeutic agents, as well as the new treatment strategies related to immunotherapy in solid tumors, are carefully discussed throughout this review.
Description: p. 227–240.: il. p&b.
URI: http://sr-vmlxaph03:8080/jspui/handle/123456789/4820
ISSN: 1432-0843
Appears in Collections:Artigos de Periódicos da área de Ginecologia

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