Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/4925
Title: Efficacy of v-3 supplementation on nutritional status, skeletal muscle, and chemoradiotherapy toxicity in cervical cancer patients: A randomized, triple-blind, clinical trial conducted in a middle-income country
Authors: Chaves, Gabriela Villaça
Aredes, Mariah Azevedo
Camara, Alex Oliveira da
Paula, Nathália Silva de
Carmo, Maria das Gracas Tavares do
Fraga, Karla Yasmin Dias
Keywords: Neoplasias do Colo do Útero
Uterine Cervical Neoplasms
Tomógrafos Computadorizados
Tomography Scanners X-Ray Computed
Composição Corporal
Body Composition
Estado Nutricional
Nutritional Status
Cisto do Colédoco
Choledochal Cyst
Músculo Esquelético
Muscle, Skeletal
Issue Date: 2019
Publisher: Nutrition
Citation: CHAVES, Gabriela Villaça et al. Efficacy of v-3 supplementation on nutritional status, skeletal muscle, and chemoradiotherapy toxicity in cervical cancer patients: A randomized, triple-blind, clinical trial conducted in a middle-income country. Nutrition, p. 67-68, 2019.
Abstract: Supplementation with v-3 has been shown to favor the preservation of body weight and skeletal muscle. The aim of this study was to evaluate the efficacy of v-3 supplementation on nutritional status, skel etal muscle quantity and quality, and toxicity for treatment of women with cervical cancer. Methods: This was a randomized, triple-blinded, placebo-controlled clinical trial in women diagnosed with cervical cancer who underwent chemoradiotherapy between March 2016 and August 2017. The intervention group received four capsules with v-3 (2.5 g/d) and the control group (CG) received the same number of identical-looking capsules with olive oil, for 45 d. Nutritional status was measured by anthropometry and Patient-Generated Subjective Global Assessment. Body composition was assessed by computed tomography. The skeletal muscle index was calculated using the range 29 to +150 HU. For skeletal muscle quality, the area comprised between 29 and +29 HU was denominated low-radiodensity skeletal muscle index and the range between +30 and +150 HU high-radiodensity skeletal muscle index, representing the skeletal mus cle area with high or low intramuscular fat infiltration, respectively. Results: The study population comprised 40 patients, with an average age 44.53 § 8.73. The intervention group maintained body weight and showed an improvement in Patient-Generated Subjective Global Assessment score. A significant reduction in skeletal muscle index was observed in both groups. However, in regard to skel etal muscle quality, patients in the intervention group preserved low- and high-radiodensity skeletal muscle index, whereas those in the control group had increased low-radiodensity skeletal muscle index and signifi cantly reduced high-radiodensity skeletal muscle index, reflecting high intramuscular fat infiltration only in the control group. The incidence of chemotherapy toxicity was significantly lower in the intervention group. Conclusions: The results suggest that v-3 supplementation is effective in maintaining nutritional status, skel etal muscle quality, and reduced symptoms of chemoradiotherapy among women with cervical cancer.
Description: p. 67-68.: il. p&b.
URI: http://sr-vmlxaph03:8080/jspui/handle/123456789/4925
ISSN: 0899-9007
Appears in Collections:Artigos de Periódicos da área de Nutrição



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