Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/5003
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dc.contributor.authorSilva, De´bora Santos da-
dc.contributor.authorTeixeira, Lisandra Antonia Castro-
dc.contributor.authorBeghini, Daniela Gois-
dc.contributor.authorPinho, Ma´rcia de Berredo Moreira-
dc.contributor.authorRosa, Patricia Sammarco-
dc.contributor.authorRibeiro, Marli Rambaldi-
dc.contributor.authorFreire, Monica Di Calafiori-
dc.contributor.authorHacker, Mariana de Andréa Vilas Boas-
dc.contributor.authorPessolani, Maria Cristina Vidal-
dc.contributor.authorTovar, Ana Maria Freire-
dc.contributor.authorSarno, Euzenir Nunes-
dc.contributor.authorPerales, Jonas-
dc.contributor.authorBozza, Fernando Augusto-
dc.contributor.authorEsquenazi, Danuza-
dc.contributor.authorMonteiro, Robson de Queiroz-
dc.contributor.authorLara, Flavio Alves-
dc.contributor.authorFerreira, André Teixeira da Silva-
dc.contributor.authorNery, José Augusto da Costa-
dc.date.accessioned2022-02-03T17:32:28Z-
dc.date.available2022-02-03T17:32:28Z-
dc.date.issued2018-
dc.identifier.issn1935-2735-
dc.identifier.urihttp://sr-vmlxaph03:8080/jspui/handle/123456789/5003-
dc.descriptionp. 1-20.: il. color.-
dc.description.abstractLeprosy is a chronic dermato-neurological disease caused by Mycobacterium leprae infec tion. In 2016, more than 200,000 new cases of leprosy were detected around the world, rep resenting the most frequent cause of infectious irreversible deformities and disabilit Principal findings In the present work, we demonstrate a consistent procoagulant profile on 40 reactional and non-reactional multibacillary leprosy patients. A retrospective analysis in search of signs of coagulation abnormalities among 638 leprosy patients identified 35 leprosy patients (5.48%) which displayed a characteristic lipid-like clot formed between blood clot and serum during serum harvesting, herein named ‘leprosum clot’. Most of these patients (n = 16, 45.7%) belonged to the lepromatous leprosy pole of the disease. In addition, formation of the leprosum clot was directly correlated with increased plasma levels of soluble tissue fac tor and von Willebrand factor. High performance thin layer chromatography demonstrated a high content of neutral lipids in the leprosum clot, and proteomic analysis demonstrated that the leprosum clot presented in these patients is highly enriched in fibrin. Remarkably, differ ential 2D-proteomics analysis between leprosum clots and control clots identified two pro teins present only in leprosy patients clots: complement component 3 and 4 and inter alpha-trypsin inhibitor family heavy chain-related protein (IHRP). In agreement with those observations we demonstrated that M. leprae induces hepatocytes release of IHRP in vitro. Conclusions We demonstrated that leprosy MB patients develop a procoagulant status due to high levels of plasmatic fibrinogen, anti-cardiolipin antibodies, von Willebrand factor and soluble tissue factor. We propose that some of these components, fibrinogen for example, presents poten tial as predictive biomarkers of leprosy reactions, generating tools for earlier diagnosis and treatment of these events.-
dc.publisherPLOS Neglected Tropical Diseasespt_BR
dc.subjectHanseníasept_BR
dc.subjectLeprosypt_BR
dc.subjectDoença Crônicapt_BR
dc.subjectChronic Diseasept_BR
dc.subjectMycobacteriumpt_BR
dc.subjectAnormalidades Congênitaspt_BR
dc.subjectCongenital Abnormalitiespt_BR
dc.subjectPessoas com Deficiênciapt_BR
dc.subjectDisabled Personspt_BR
dc.subjectCoagulação Sanguíneapt_BR
dc.subjectBlood Coagulationpt_BR
dc.subjectPacientespt_BR
dc.subjectPatientspt_BR
dc.subjectCianosept_BR
dc.subjectNecrosept_BR
dc.titleBlood coagulation abnormalities in multibacillary leprosy patientspt_BR
dc.TypeArticlept_BR
Appears in Collections:Artigos de Periódicos da área de Terapia Intensiva



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