Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/6178
Full metadata record
DC FieldValueLanguage
dc.contributor.authorPalumbo Júnior, Antonio-
dc.contributor.authorSousa, Vanessa Paiva Leite de-
dc.contributor.authorEsposito, Francesco-
dc.contributor.authorMartino, Marco de-
dc.contributor.authorForzati, Floriana-
dc.contributor.authorMoreira, Fábio Carvalho de Barros-
dc.contributor.authorSimão, Tatiana de Almeida-
dc.contributor.authorNasciutti, Luiz Eurico-
dc.contributor.authorFusco, Alfredo-
dc.contributor.authorPinto, Luis Felipe Ribeiro-
dc.contributor.authorChaves, Cláudia Bessa Pereira-
dc.contributor.authorCosta, Nathalia de Oliveira Meireles da-
dc.date.accessioned2022-03-30T19:45:35Z-
dc.date.available2022-03-30T19:45:35Z-
dc.date.issued2019-05-
dc.identifier.issn2073-4425-
dc.identifier.other10.3390/genes10050372-
dc.identifier.urihttp://sr-vmlxaph03:8080/jspui/handle/123456789/6178-
dc.description.abstractEndometrioid endometrial carcinomas (EEC) are the most common malignant gynecologic tumors. Despite the increase in EEC molecular knowledge, the identification of new biomarkers involved in disease’s development and/or progression would represent an improvement in its course. High-mobility group A protein (HMGA) family members are frequently overexpressed in a wide range of malignancies, correlating with a poor prognosis. Thus, the aim of this study was to analyze HMGA1 and HMGA2 expression pattern and their potential role as EEC biomarkers. HMGA1 and HMGA2 expression was initially evaluated in a series of 46 EEC tumors (stages IA to IV), and the findings were then validated in The Cancer Genome Atlas (TCGA) EEC cohort, comprising 381 EEC tumors (stages IA to IV). Our results reveal that HMGA1 and HMGA2 mRNA and protein are overexpressed in ECC, but only HMGA1 expression is associated with increased histological grade and tumor size. Moreover, HMGA1 but not HMGA2 overexpression was identified as a negative prognostic factor to EEC patients. Finally, a positive correlation between expression of HMGA1 pseudogenes—HMGA1-P6 and HMGA1-P7—and HMGA1 itself was detected, suggesting HMGA1 pseudogenes may play a role in HMGA1 expression regulation in EEC. Thus, these results indicate that HMGA1 overexpression possesses a potential role as a prognostic biomarker for EEC.pt_BR
dc.language.isoenpt_BR
dc.publisherGenespt_BR
dc.subjectEndometrial Neoplasmspt_BR
dc.subjectEndometrial Carcinomapt_BR
dc.subjectDisease Progressionpt_BR
dc.subjectBiomarkerspt_BR
dc.subjectMolecular Biomarkerspt_BR
dc.titleOverexpression of HMGA1 Figures as a Potential Prognostic Factor in Endometrioid Endometrial Carcinoma (EEC)pt_BR
dc.TypeArticlept_BR
Appears in Collections:Artigo de Periódicos da Pesquisa Clínica



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.