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https://ninho.inca.gov.br/jspui/handle/123456789/6510| Title: | Presence of CD34+ in Megakaryocytes in Association With p53 Expression Predicts Unfavorable Prognosis in Low-risk Myelodysplastic Syndrome Patients |
| Authors: | Santos, Talyta Ellen de Jesus dos Duarte, Fernando Barroso Barbosa, Maritza Cavalcante Moura, Anna Thawanny Gadelha Vasconcelos, João Paulo Leitão de Rocha-Filho, Francisco Dário Coutinho, Diego Ferreira Vasconcelos, Paulo R. L. Garcia, Yhasmine Delles Oliveira Lemes, Romélia Pinheiro Gonçalves Renault, Ilana Zalcberg |
| Keywords: | Síndromes Mielodisplásicas Myelodysplastic Syndromes Antígenos CD34 Antigens, CD34 Megacariócitos Megakaryocytes Proteína Supressora de Tumor p53 Tumor Suppressor Protein p53 Prognóstico Prognosis |
| Issue Date: | 2019 |
| Publisher: | In vivo |
| Abstract: | Background/Aim: Although risk stratification using the Prognostic Scores Systems (IPSS, WPSS and IPSSR) incorporate key information about prognosis of patients with Myelodysplastic syndromes (MDS), patients classified as low-risk may evolve rapidly and aggressively, despite a “favorable” prognostic stratification. The aim of this study was to identify biomarkers for predicting prognosis, and for better stratification and management of these patients. Materials and Methods: Expression of CD34 and p53 in megakaryocytes was examined by immunohistochemistry in 71 MDS patients classified as low-risk. Results: CD34 staining in megakaryocytes was associated with p53 expression (p=0.0166). CD34 and p53 expression were associated to worse overall survival in patients (p=0.0281). Conclusion: The presence of CD34 in megakaryocytes is associated with p53 expression and an adverse prognosis for MDS patients |
| URI: | http://sr-vmlxaph03:8080/jspui/handle/123456789/6510 |
| ISSN: | 1791-7549 |
| Appears in Collections: | Artigo de Periódicos da Pesquisa Clínica |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| in_vivo-33-277.pdf | 158.15 kB | Adobe PDF | View/Open |
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