Association between nutritional status and muscle strength in pediatric cancer patients

Abstract

Background & aims: Cancer provides a catabolic state, leading to weight loss and depletion of lean mass, which is accompanied by loss of muscle strength in pediatric patients. Muscle strength is considered a predictor of nutritional status. The aim was to evaluate the association between nutritional status and muscle strength in pediatric cancer patients hospitalized at the Cancer Hospital I. Methods: A cross-sectional study was carried out with cancer patients aged 6e19 years hospitalized in the period from February to November 2019. In the first 48 h of hospitalization, anthropometric (body weight, height, mid-upper arm circumference - MUAC, tricipital skinfold - TSF, calculated body mass index e BMI and mid-arm muscle circumference e MAMC) and handgrip strength (HGS) assessments were performed. The statistical analysis for the data correlation was performed using Pearson's coefficient, linear regression, and association by c2 test. The HGS values were distributed in quartiles. P-value < 0.05 was considered significant. Results: The sample consisted of 63 patients, 52.40% male and 47.60% female. The mean age was 13.01 (±3.83; 6.20e19.78) years. The frequency of adequate BMI was 45.60% and the mean HGS was 17.10 kg (±8.93). There was a strong positive correlation between HGS and MAMC and weight (r ¼ 0.743; p < 0,001 and r ¼ 0.706; p < 0,001, respectively), and association with MAMC independently of age and sex. According to quartile distribution, the lowest HGS quartile also showed association with below adequate MAMC (p ¼ 0.005). Conclusions: These results showed muscle strength was associated with nutritional status and low muscle strength was associated with low muscle mass, independently of age and sex.

: Cancer provides a catabolic state, leading to weight loss and depletion of lean mass, which is accompanied by loss of muscle strength in pediatric patients. Muscle strength is considered a predictor of nutritional status. The aim was to evaluate the association between nutritional status and muscle strength in pediatric cancer patients hospitalized at the Cancer Hospital I. Methods: A cross-sectional study was carried out with cancer patients aged 6e19 years hospitalized in the period from February to November 2019. In the first 48 h of hospitalization, anthropometric (body weight, height, mid-upper arm circumference - MUAC, tricipital skinfold - TSF, calculated body mass index e BMI and mid-arm muscle circumference e MAMC) and handgrip strength (HGS) assessments were performed. The statistical analysis for the data correlation was performed using Pearson's coeffi cient, linear regression, and association by c2 test. The HGS values were distributed in quartiles. P-value < 0.05 was considered significant. Results: The sample consisted of 63 patients, 52.40% male and 47.60% female. The mean age was 13.01 (±3.83; 6.20e19.78) years. The frequency of adequate BMI was 45.60% and the mean HGS was 17.10 kg (±8.93). There was a strong positive correlation between HGS and MAMC and weight (r ¼ 0.743; p < 0,001 and r ¼ 0.706; p < 0,001, respectively), and association with MAMC independently of age and sex. According to quartile distribution, the lowest HGS quartile also showed association with below adequate MAMC (p ¼ 0.005). Conclusions: These results showed muscle strength was associated with nutritional status and low muscle strength was associated with low muscle mass, independently of age and sex.