Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/6924
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dc.contributor.authorAndrade, Francianne Gomes-
dc.contributor.authorGonçalves, Bruno Alves de Aguiar-
dc.contributor.authorThuler, Luiz Claudio Santos-
dc.contributor.authorBarbosa, Thayana da Conceição-
dc.contributor.authorEmerenciano, Mariana-
dc.contributor.authorSiqueira, André-
dc.contributor.authorPombo-de-Oliveira, Maria do Socorro-
dc.contributor.authorBrazilian Collaborative Study Group of Infant Acute Leukemia-
dc.contributor.authorFurtado e Silva, Juliana Montibeller-
dc.date.accessioned2022-05-13T14:06:46Z-
dc.date.available2022-05-13T14:06:46Z-
dc.date.issued2014-
dc.identifier.issn1471-2407-
dc.identifier.otherdoi: 10.1186/1471-2407-14-133-
dc.identifier.urihttp://sr-vmlxaph03:8080/jspui/handle/123456789/6924-
dc.description.abstractBackground: Deregulation of the MAPK genes signalling caused by somatic mutations have been implied in leukaemia pathogenesis, including RAS mutation (RASmut) in acute myeloid leukaemia (AML), which has been associated with intra-uterine chemical exposures. A case-case study was conducted in order to explore maternal and child exposures to tobacco smoking associations with early age leukaemia (EAL). Methods: Covariables of reference were MLL rearrangements (MLL-r), RASmut and NQO1 rs1800566 (C609T). Samples from 150 acute lymphoblastic leukaemia (ALL) and 85 AML were included. Maternal exposures were assessed using a structured questionnaire with demographic, personal habits and residence history information. Restriction fragment length polymorphism and denaturing high performance liquid chromatography were used to screen FLT3, KRAS, and NRAS mutations; direct sequencing was performed to validate the results. NQO1 polymorphism was detected by real-time allelic discrimination technique. Results: Overall, RASmut were detected in 28.7% of EAL cases; BRAFmut was found only in one AML patient. Higher rate of KRASmut was found in ALL (30.3%) compared to AML (20.8%) with MLL-r; RASmut showed an association with second-hand tobacco smoking exposures (OR, 3.06, 95% CI, 1.03-9.07). A considerable increased risk for EAL with the combination of RASmut and NQO1 609CT (OR, 4.24, 95% CI, 1.24-14.50) was observed. Conclusions: Our data demonstrated the increased risk association between maternal smoking and EAL with MLL-r. Additionally, suggests that children second-hand tobacco exposures are associated with increased risk of EAL with RASmut modulated by NQO1 rs1800566 (C609T).pt_BR
dc.language.isoenpt_BR
dc.publisherBioMed Central cancerpt_BR
dc.subjectGenes raspt_BR
dc.subjectLeucemia Mieloide Agudapt_BR
dc.subjectLeukemia, Myeloid, Acutept_BR
dc.subjectProteínas Quinases Ativadas por Mitógenopt_BR
dc.subjectMitogen-Activated Protein Kinasespt_BR
dc.subjectNAD(P)H Desidrogenase (Quinona)pt_BR
dc.subjectNAD(P)H Dehydrogenase (Quinone)pt_BR
dc.subjectPoluição por Fumaça de Tabacopt_BR
dc.subjectTobacco Smoke Pollutionpt_BR
dc.subjectContaminación por Humo de Tabacopt_BR
dc.subjectTranslocação Genéticapt_BR
dc.subjectTranslocation Geneticpt_BR
dc.titleRAS mutations in early age leukaemia modulated by NQO1 rs1800566 (C609T) are associated with second-hand smoking exposurespt_BR
dc.TypeArticlept_BR
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