Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/6943
Title: Polymorphisms in CYP1B1, CYP3A5, GSTT1, and SULT1A1 Are Associated with Early Age Acute Leukemia
Authors: Lopes, Bruno de Almeida
Emerenciano, Mariana
Gonçalves, Bruno Alves de Aguiar
Vieira, Tállita Meciany Farias
Rossini, Ana
Pombo-de-Oliveira, Maria do Socorro
Keywords: Leucemia Mieloide Aguda
Leukemia, Myeloid, Acute
Células Precursoras de Linfócitos T
Precursor Cells, T-Lymphoid
Citocromo P-450 CYP2A6
Cytochrome P-450 CYP2A6
Fatores Sexuais
Sex Factors
Factores Sexuales
Polimorfismo de Nucleotídeo Único
Polymorphism, Single Nucleotide
Polimorfismo de Nucleótido Simple
Issue Date: 2015
Publisher: PloS one.
Abstract: Based on observational studies, early age leukemia (EAL) was associated with maternal hormone exposure during pregnancy. We studied the association between genetic polymorphisms of estrogen metabolism and EAL. Using data from the Brazilian Collaborative Study Group of Infant Acute Leukemia (2000–2012), 350 cases and 404 age-matched controls and 134 mothers of cases and controls were genotyped to explore polymorphisms in genes of the estrogen metabolism pathway: CYP1B1 (c.1294C>G, rs1056836), CYP3A4 (c.-392A>G, rs2740574), CYP3A5 (c.219-237G>A, rs776746), GSTM1/GSTT1 deletions, and SULT1A1 (c.638G>A, rs9282861; and c.667A>G, rs1801030). Logistic regression was used to calculate the odds ratios (OR) with 95% confidence intervals (CIs), and unconditional logistic regression was used to estimate adjusted odds ratios (aORs) by ethnicity. Because of multiple testing, p values < 0.01 were significant after Bonferroni correction. SULT1A1 (c.638G>A) was associated to infant acute lymphoblastic leukemia and acute myeloid leukemia (AML) risk in males (additive model: aOR = 0.52; 95% CI: 0.29–0.95, p = 0.03; dominant model: aOR = 2.18; 95% CI: 1.17–4.05, p = 0.01, respectively). CYP1B1 polymorphism was associated with a decreased risk of AML either for non-white or female children (additive model: OR = 0.24; 95% CI: 0.08–0.76, p < 0.01; additive model: aOR = 0.27; 95% CI: 0.08–0.89, p = 0.03, respectively). Since polymorphisms of Cytochrome P450 genes presented gender-specific risk associations, we also investigated their expression. CYP1B1 was not expressed in 57.1% of EAL cases, and its expression varied by genotype, gender, and leukemia subtype. Maternal-fetal GSTT1 null genotype was associated with risk of EAL. This study shows that polymorphisms in genes of estrogen metabolism confer genetic susceptibility to EAL, mainly in males, and maternal susceptibility genes modify the risk for developing EAL in newborns
URI: http://sr-vmlxaph03:8080/jspui/handle/123456789/6943
ISSN: 1932-6203
Appears in Collections:Artigo de Periódicos da Pesquisa Clínica

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