Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/6947
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dc.contributor.authorSilva, Gustavo Telles da-
dc.contributor.authorBergmann, Anke-
dc.contributor.authorThuler, Luiz Claudio Santos-
dc.date.accessioned2022-05-17T13:11:31Z-
dc.date.available2022-05-17T13:11:31Z-
dc.date.issued2019-
dc.identifier.issn2476-762X-
dc.identifier.other10.31557/APJCP.2019.20.1.45-
dc.identifier.urihttp://sr-vmlxaph03:8080/jspui/handle/123456789/6947-
dc.description.abstractBackground: Bone is a frequent site of metastasis from various primary cancers including with Non-Small Cell Lung Cancer. The aim of this study was to investigate the incidence and risk factors for Bone Metastasis in patients with Non-Small Cell Lung Cancer. Methodology: A cohort study was carried out in patients diagnosed with Non-Small Cell Lung Cancer between 2006 and 2014 in a single cancer centre. A descriptive analysis of the population was compiled based on mean± standard deviation (SD) for continuous variables and percentage (%) for categorical variables. Univariate and multivariate Cox proportional hazards regression analyses were carried out to quantify the relationship between independent variables and the outcome variable (Bone Metastasis). Results: During the study period 1025 patients were diagnosed with Non-Small Cell Lung Cancer. Bone Metastasis was detected in 136 patients (13.2%) with a mean interval between Non-Small Cell Lung Cancer diagnosis and Bone Metastasis of 8.07 months (95% CI: 7.68 8.45). Multivariate analysis revealed that younger age (HR 0.97; 95%CI, 0.95–0.99; p=0.002), adenocarcinoma (HR 1.51; 95%CI, 1.06–2.15; p=0.021) and treatment with chemotherapy, radiotherapy or chemotherapy combined with radiotherapy (HR 3.73; 95%CI, 2.30–6.05; p<0.001) were associated with the occurrence of Bone Metastasis. Conclusion: The incidence of Bone Metastasis was 13.2%. Younger age, histological subtype adenocarcinoma and treatment with chemotherapy, radiotherapy or chemotherapy combined with radiotherapy are independent risk factors for Bone Metastasis.pt_BR
dc.language.isoenpt_BR
dc.publisherAsian Pacific Organization of Cancer Preventionpt_BR
dc.subjectNon-Small Cell Lung Cancerpt_BR
dc.subjectCáncer de Pulmón de Células no Pequeñaspt_BR
dc.subjectCarcinoma de Pulmão de não Pequenas Célulaspt_BR
dc.subjectCarcinoma, Non-Small-Cell Lungpt_BR
dc.subjectCarcinoma Pulmonar de Células não Pequenaspt_BR
dc.subjectCarcinoma de Pulmón de Células no Pequeñaspt_BR
dc.subjectRisk Factorspt_BR
dc.subjectFatores de Riscopt_BR
dc.subjectFactores de Riesgopt_BR
dc.subjectIncidencept_BR
dc.subjectIncidênciapt_BR
dc.subjectIncidenciapt_BR
dc.subject.otherBone Metastasisen
dc.titleIncidence and Risk Factors for Bone Metastasis in Non-Small Cell Lung Cancerpt_BR
dc.TypeArticlept_BR
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