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https://ninho.inca.gov.br/jspui/handle/123456789/8908| Title: | Evaluation and comparison of a new DOTA and DTPA-bombesin agonist in vitro and in vivo in low and high GRPR expressing prostate and breast tumor models |
| Authors: | Pujatti, Priscilla Brunelli Foster, Julie Finucane, Ciara Hudson, Chantelle Burnet, Jerome Pasqualoto, Kerly Fernanda Mesquita Mengatti, Jair Mather, Stephen Araújo, Elaine Bortoleti de Sosabowski, Jane |
| Keywords: | Bombesina Bombesin Ácido Pentético Pentetic Acid GRPR Estudos de Casos e Controles Case-Control Studies DOTA |
| Issue Date: | 2015 |
| Publisher: | pplied Radiation and Isotopes |
| Citation: | PUJATTI, Priscilla Brunelli et al. Evaluation and comparison of a new DOTA and DTPA-bombesin agonist in vitro and in vivo in low and high GRPR expressing prostate and breast tumor models. pplied Radiation and Isotopes, v. 96, p. 91–101, 2015. |
| Abstract: | We evaluated and compared a new bombesin analog [Tyr–Gly5, Nle14]-BBN(6–14) conjugated to DOTA or DTPA and radiolabeled with In-111 in low and high GRPR expressing tumor models. Both peptides were radiolabeled with high radiochemical purity and specific activity. In vitro assays on T-47D, LNCaP and PC3 cells showed that the affinity of peptides is similar and a higher binding and internalization of DOTApeptide to PC-3 cells was observed. Both peptides could target PC-3 and LNCaP tumors in vivo and both tumor types could be visualized by microSPECT/CT. |
| Description: | p. 91–101.: il. p&b. e color. |
| URI: | http://sr-vmlxaph03:8080/jspui/handle/123456789/8908 |
| Appears in Collections: | Artigos de Periódicos da área de Farmácia |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Evaluation and comparison of a new DOTA and DTPA-bombesin agonist in vitro and in vivo in low and high GRPR expressing prostate and breast tumor models..pdf | 2.08 MB | Adobe PDF | View/Open |
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