Preparation of [In-111]-labeled-DTPA-bombesin conjugates at high specific activity and stability: Evaluation of labeling parameters and potential stabilizers

Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/8919

Title:	Preparation of [In-111]-labeled-DTPA-bombesin conjugates at high specific activity and stability: Evaluation of labeling parameters and potential stabilizers
Authors:	Pujatti, Priscilla Brunelli Massicano, Adriana Vidal Fernandes Mengatti, Jair Araújo, Elaine Bortoleti de
Keywords:	Radioisótopos de Índio Indium Radioisotopes Bombesina Bombesin Cromatografia Chromatography Excipientes Excipients Índio 111 Indium 111
Issue Date:	2012
Publisher:	Applied Radiation and Isotopes
Citation:	PUJATTI, Priscilla Brunelli et al. Preparation of [In-111]-labeled-DTPA-bombesin conjugates at high specific activity and stability: Evaluation of labeling parameters and potential stabilizers. Applied Radiation and Isotopes, v. 70, p. 856–863, 2012.
Abstract:	The aim of the present work was to obtain stabilized high specific activity (HSA) 111In-labeled bombesin conjugates for preclinical evaluations. Parameters influencing the kinetics of labeling were investigated and the effect of stabilizers on HSA radiopeptides stability at room temperature were systematically categorized applying chromatography techniques. A SA of 174 GBq/mmol was achieved with high radiochemical purity, but the labeled compounds exhibited low stability. The addition of stabilizers avoided their radiolysis and significantly increased their stability.
Description:	p. 856–863.: il. p&b.
URI:	http://sr-vmlxaph03:8080/jspui/handle/123456789/8919
Appears in Collections:	Artigos de Periódicos da área de Farmácia

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