Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/9696
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dc.contributor.authorNogueira, Cristiane Alves Villela-
dc.contributor.authorLeite, Nathalie Carvalho-
dc.contributor.authorPanke, Carine Luíze-
dc.contributor.authorTovo, Cristiane Valle-
dc.contributor.authorCoral, Gabriela Perdomo-
dc.contributor.authorFernandes, Sabrina-
dc.contributor.authorBuss, Caroline-
dc.contributor.authorPort, Gabriela Zanatta-
dc.contributor.authorCardoso, Ana Carolina-
dc.contributor.authorBarroso, Cláudia Cravo Moreira-
dc.contributor.authorCalçado, Fernanda Luiza Valladares-
dc.contributor.authorRezende, Guilherme Ferreira da Motta-
dc.contributor.authorCampos, Carlos Frederico Ferreira-
dc.contributor.authorAraújo Neto, João Marcello de-
dc.contributor.authorPerez, Renata de Mello-
dc.contributor.authorCoelho, Henrique Sérgio Moraes-
dc.contributor.authorMattos, Angelo Alves de-
dc.date.accessioned2022-08-01T17:36:42Z-
dc.date.available2022-08-01T17:36:42Z-
dc.date.issued2019-
dc.identifier.citationNOGUEIRA, Cristiane Alves Villela et al. Transient hepatic elastography has the best performance to evaluate liver fibrosis in non-alcoholic fatty liver disease (NAFLD). Annals of Hepatology, v. 18, p. 445–449, 2019.-
dc.identifier.issn1665-2681-
dc.identifier.urihttp://sr-vmlxaph03:8080/jspui/handle/123456789/9696-
dc.descriptionp. 445–449.: il. color.-
dc.description.abstractThe gold-standard for fibrosis diagnosis in non-alcoholic fatty liver disease (NAFLD) is liver biopsy, despite its invasive approach, sampling limitations and variability among observers. The objective was to validate the performance of non-invasive methods (FibroscanTM; APRI, FIB4 and NAFLD score) comparing with liver biopsy in the evaluation of liver fibrosis in patients with NAFLD. Material and methods: NAFLD patients ≥18 years of age who were submitted to liver biopsy were included and evaluated at two reference tertiary hospitals in Brazil with transient hepatic elastography (THE) assessment through FibroscanTM, APRI, FIB4 and NAFLD scores were determined. Sensitivity, specificity, positive (PPV) and negative (NPV) predictive values for the diagnosis of advanced fibrosis were calculated to evaluate the performance of these non-invasive methods in NAFLD patients, adopting liver biopsy as the gold standard. Results: A total of 104 patients were studied. At three different cutoff values (7.9, 8.7 and 9.6 kPa) THE presented the highest sensitivity values (95%, 90% and 85% respectively), and the highest NPV (98%, 96.4% and 95.1% respectively) for the diagnosis of advanced fibrosis. It also presented the highest AUROC (0.87; CI 95% 0.78–0.97). Conclusion: When compared to the gold standard, transient hepatic elastography presented the best performance for the diagnosis and exclusion of advanced fibrosis in patients with NAFLD, overcoming APRI, FIB4 and NAFLD score.-
dc.publisherAnnals of Hepatologypt_BR
dc.subjectFígado Gordurosopt_BR
dc.subjectFatty Liverpt_BR
dc.subjectHepatopatia Gordurosa não Alcoólicapt_BR
dc.subjectNon-alcoholic Fatty Liver Diseasept_BR
dc.subjectHígado Graso-
dc.titleTransient hepatic elastography has the best performance to evaluate liver fibrosis in non-alcoholic fatty liver disease (NAFLD)pt_BR
dc.TypeArticlept_BR
Appears in Collections:Artigos de Periódicos da área de Pronto Atendimento Interno



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