Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/9704
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dc.contributor.authorMeyer, Claus-
dc.contributor.authorBurmeister, Thomas-
dc.contributor.authorGröger, Daniela-
dc.contributor.authorTsaur, Grigory-
dc.contributor.authorFechina, Larisa-
dc.contributor.authorRenneville, Aline-
dc.contributor.authorSutton, Rosemary-
dc.contributor.authorVenn, Nicola C.-
dc.contributor.authorEmerenciano, Mariana-
dc.contributor.authorPombo-de-Oliveira, Maria do Socorro-
dc.contributor.authorBlunck, Caroline Barbieri-
dc.contributor.authorLopes, Bruno de Almeida-
dc.contributor.authorZuna, Jan-
dc.contributor.authorTrka, Jan-
dc.contributor.authorBallerini, Paola-
dc.contributor.authorLapillonne, Hélène-
dc.contributor.authorBraekeleer, Marc de-
dc.contributor.authorCazzaniga, Giovanni-
dc.contributor.authorCorral Abascal, Lilia-
dc.contributor.authorVelden, Vincent H. J. Van der-
dc.contributor.authorDelabesse, Eric-
dc.contributor.authorPark, Tae Sung-
dc.contributor.authorOh, Song Hee-
dc.contributor.authorSilva, Maria Luiza Macedo-
dc.contributor.authorLund-Aho, Tiina-
dc.contributor.authorJuvonen, Vesa-
dc.contributor.authorMoore, Andrew S-
dc.contributor.authorHeidenreich, Olaf-
dc.contributor.authorVormoor, Josef-
dc.contributor.authorZerkalenkova, Elena-
dc.contributor.authorOlshanskaya, Yulia-
dc.contributor.authorBueno, Clara-
dc.contributor.authorMenendez, Pablo-
dc.contributor.authorTeigler-Schlegel, Andrea-
dc.contributor.authorStadt, Udo Zur-
dc.contributor.authorLentes, Jana-
dc.contributor.authorGöhring, Gudrun-
dc.contributor.authorKustanovich, Anatoly-
dc.contributor.authorAleinikova, Olga-
dc.contributor.authorSchäfer, Beat W-
dc.contributor.authorKubetzko, Susanne-
dc.contributor.authorMadsen, Hans O.-
dc.contributor.authorGruhn, Bernd-
dc.contributor.authorDuarte, Ximo-
dc.contributor.authorGameiro, Paula-
dc.contributor.authorLippert, Eric-
dc.contributor.authorBidet, Audrey-
dc.contributor.authorCayuela, Jean-Michel-
dc.contributor.authorClappier, Emmanuelle-
dc.contributor.authorAlonso, Cristina N.-
dc.contributor.authorEibrink, Marry M, Van den Heuvel-
dc.contributor.authorIzraeli, Shai-
dc.contributor.authorTrakhtenbrot, Luba-
dc.contributor.authorArcher, Paul-
dc.contributor.authorHancock, Jeremy-
dc.contributor.authorMöricke, Anja-
dc.contributor.authorAlten, Julia-
dc.contributor.authorSchrappe, Martin-
dc.contributor.authorStanulla, Martin-
dc.contributor.authorStrehl, Sabine-
dc.contributor.authorAttarbaschi, Andishe-
dc.contributor.authorDworzak, Michael-
dc.contributor.authorHaas, Oskar A-
dc.contributor.authorPanzer-Grümayer, Renate-
dc.contributor.authorSedék, Lukasz-
dc.contributor.authorSzczepanski, Tomasz-
dc.contributor.authorCaye, Aurélie-
dc.contributor.authorSuarez, Lilia-
dc.contributor.authorCavé, Hélène-
dc.contributor.authorMarschalek, Rolf-
dc.contributor.authorZwaan, Christian Michel-
dc.date.accessioned2022-08-01T19:18:11Z-
dc.date.available2022-08-01T19:18:11Z-
dc.date.issued2018-
dc.identifier.issn1476-5551-
dc.identifier.otherDoi: 10.1038/leu.2017.213. Epub 2017 Jul 13.-
dc.identifier.urihttp://sr-vmlxaph03:8080/jspui/handle/123456789/9704-
dc.description.abstractChromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained from 2345 acute leukemia patients. Genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) were determined and 11 novel TPGs were identified. Thus, a total of 135 different MLL rearrangements have been identified so far, of which 94 TPGs are now characterized at the molecular level. In all, 35 out of these 94 TPGs occur recurrently, but only 9 specific gene fusions account for more than 90% of all illegitimate recombinations of the MLL gene. We observed an age-dependent breakpoint shift with breakpoints localizing within MLL intron 11 associated with acute lymphoblastic leukemia and younger patients, while breakpoints in MLL intron 9 predominate in AML or older patients. The molecular characterization of MLL breakpoints suggests different etiologies in the different age groups and allows the correlation of functional domains of the MLL gene with clinical outcome. This study provides a comprehensive analysis of the MLL recombinome in acute leukemia and demonstrates that the establishment of patient-specific chromosomal fusion sites allows the design of specific PCR primers for minimal residual disease analyses for all patients.pt_BR
dc.language.isootherpt_BR
dc.publisherLeukemiapt_BR
dc.subjectAberrações Cromossômicaspt_BR
dc.subjectChromosome Aberrationspt_BR
dc.subjectAberraciones Cromosómicaspt_BR
dc.subjectQuebra Cromossômicapt_BR
dc.subjectChromosome Breakagept_BR
dc.subjectRotura Cromosómicapt_BR
dc.subjectRearranjo Gênico/genéticapt_BR
dc.subjectGene Rearrangement/geneticspt_BR
dc.subjectReordenamiento Génico/genéticapt_BR
dc.subjectHistona-Lisina N-Metiltransferasept_BR
dc.subjectHistone-Lysine N-Methyltransferasept_BR
dc.subjectN-Metiltransferasa de Histona-Lisinapt_BR
dc.subjectLeucemia Mieloide Agudapt_BR
dc.subjectLeukemia, Myeloid, Acutept_BR
dc.subjectProteína de Leucina Linfoide-Mieloidept_BR
dc.subjectMyeloid-Lymphoid Leukemia Proteinpt_BR
dc.subjectProteína de la Leucemia Mieloide-Linfoidept_BR
dc.subjectProteínas de Fusão Oncogênicapt_BR
dc.subjectOncogene Proteins, Fusionpt_BR
dc.subjectProteínas de Fusión Oncogénicapt_BR
dc.subjectLeucemia-Linfoma Linfoblástico de Células Precursoraspt_BR
dc.subjectPrecursor Cell Lymphoblastic Leukemia-Lymphomapt_BR
dc.subjectTranslocação Genéticapt_BR
dc.subjectTranslocation, Geneticpt_BR
dc.titleThe MLL recombinome of acute leukemias in 2017pt_BR
dc.TypeArticlept_BR
Appears in Collections:Artigo de Periódicos da Pesquisa Clínica

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