Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/11196
Title: Translation, cross-cultural adaptation, and validation of the lee chronic graft-versus-host disease symptom scale in a brazilian population
Authors: Souza, Clarissa Vasconcellos de
Vigorito, Afonso Celso
Miranda, Eliana Cristina Martins
Garcia Júnior, Celso
Colturato, Vergilio Antonio Rensi
Mauad, Marcos Augusto
Lima, Maria Claudia Rodrigues Moreira
Bouzas, Luis Fernando da Silva
Lermontov, Simone Pereira
Hamerschlak, Nelson
Rodrigues, Morgani
Almeida, José Carlos Barros de
Chiattone, Ricardo Rabello
Lee, Stephanie Joi
Flowers, Mary Evelyn Dantas
Keywords: Chronic graft-versus-host disease
Doença crônica do enxerto contra o hospedeiro
Lee Chronic Graft-versus-Host Disease Symptom Scale
Escala de Sintomas de Doença Enxerto-versus-Hospedeiro de Lee
Patient-reported symptoms
Sintomas relatados pelo paciente
Allogeneic hematopoietic cell transplantation
Transplante alogênico de células hematopoiéticas
Issue Date: 2016
Publisher: Biol Blood Marrow Transplant
Abstract: The Lee Chronic Graft-versus-Host Disease (GVHD) Symptom Scale is a patient-reported instrument developed and validated in English to measure the symptoms and functional impact of cGVHD. This tool has not yet been validated in a Latin American population, however. The Brazil-Seattle Chronic GVHD Consortium conducted a multicenter study at 5 Brazilian institutions to validate the Lee cGVHD Symptom Scale in adults with cGVHD. Study objectives included the translation and validation of the instrument in Brazilian Portuguese and evaluation of the correlation with other quality of life (QoL) tools, including the Medical Outcomes Study Short Form 36 (SF-36) and Functional Assessment of Chronic Illness Therapy with Bone Marrow Transplant subscale (FACT-BMT). Translation and validation were done according to the American Association of Orthopedic Surgeons Outcome Committee guidelines. Spearman’s correlation coefficient was used to measure construct validity. Reliability was assessed using Cronbach’s a and intraclass correlation coefficients. Between April 2011 and August 2012, 47 patients with cGVHD based on the 2005 National Institutes of Health criteria (29 males [62%], 18 females [38%]; median age, 48 years; range, 23 to 69 years) were enrolled in this study. The reliability of the Lee cGVHD Symptom Scale was adequate (Cronbach’s a ¼ 0.62 to 0.83). The correlations between similar domains of the Lee cGVHD Symptom Scale, SF-36, and FACT-BMT were moderate to high. Our data indicate that the Brazilian Portuguese version of the Lee cGVHD Symptom Scale is valid and reliable and can be used in clinical trials of cGVHD in Brazil.
Description: 2016 Jul;22(7):1313-1318
URI: http://sr-vmlxaph03:8080/jspui/handle/123456789/11196
Appears in Collections:Artigos de Periódicos da área de Enfermagem



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