Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/12198
Full metadata record
DC FieldValueLanguage
dc.contributor.authorCarvalho, Lilian D. S.-
dc.contributor.authorTeixeira, Leonardo Augusto Karam-
dc.contributor.authorCarrossini, Nina-
dc.contributor.authorCaldeira, Anita T. N.-
dc.contributor.authorAnsel, K. Mark-
dc.contributor.authorRao, Anjana-
dc.contributor.authorViola, Joao Paulo de Biaso-
dc.date.accessioned2023-01-02T19:15:39Z-
dc.date.available2023-01-02T19:15:39Z-
dc.date.issued2007-07-15-
dc.identifier.issn1551-4005-
dc.identifier.urihttps://ninho.inca.gov.br/jspui/handle/123456789/12198-
dc.description.abstractThe NFAT (Nuclear Factor of Activated T cells) family of transcription factors plays a central role in the regulation of several genes related to the immune response. Recently, NFAT proteins have been implicated in the proliferation and differentiation of different cell types. Previous studies have shown that NFAT1-deficient mice display lymphocyte hyperproliferation, shortened cell cycle duration, and cyclin overexpression. Here, we demonstrate that cyclin A2 expression is upregulated in the absence of NFAT1 in lymphocytes. Ectopic expression of NFAT1 in CHO cells decreases cyclin A2 levels. Indeed, NFAT1 binds to a consensus binding site found at the mouse cyclin A2 promoter in vitro and in vivo. Luciferase reporter assays show that NFAT1 downregulates cyclin A2 expression by directly binding to the cyclin A2 promoter. Together, these results indicate that the NFAT1 transcription factor represses cyclin A2 expression in lymphocytes, and may act as a silencer of gene transcription during the cell cycle.pt_BR
dc.subjectCiclinaspt_BR
dc.subjectCyclinspt_BR
dc.subjectExpressão Gênicapt_BR
dc.subjectGene Expressionpt_BR
dc.subjectLinfócitospt_BR
dc.subjectLymphocytespt_BR
dc.subjectFatores de Transcrição NFATCpt_BR
dc.subjectNFATC Transcription Factorspt_BR
dc.subjectFatores de Transcriçãopt_BR
dc.subjectTranscription Factorspt_BR
dc.titleThe NFAT1 Transcription Factor is a Repressor of Cyclin A2 Gene Expressionpt_BR
dc.TypeArticlept_BR
Appears in Collections:Artigos de Periódicos da Pesquisa Experimental e Translacional

Files in This Item:
File Description SizeFormat 
The NFAT1 Transcription Factor is a Repressor of Cyclin A2 Gene Expression.pdf1 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.