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DC Field | Value | Language |
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dc.contributor.author | Poubel, Saloê Bispo | - |
dc.contributor.author | Farias, Ticiana Della Justina | - |
dc.contributor.author | Souza, Patricia Savio de Araujo | - |
dc.contributor.author | Cintra, Ricardo | - |
dc.contributor.author | Santos, Hellen Geremias dos | - |
dc.contributor.author | Jorge, Natasha Andressa Nogueira | - |
dc.contributor.author | Castro, Mauro Antônio Alves | - |
dc.contributor.author | Wajnberg, Gabriel | - |
dc.contributor.author | Scherer, Nicole de Miranda | - |
dc.contributor.author | Genta, Maria Luiza Nogueira Dias | - |
dc.contributor.author | Carvalho, Jesus Paula | - |
dc.contributor.author | Villa, Luisa Lina | - |
dc.contributor.author | Vettorazzo, Laura Cristina Sichero | - |
dc.contributor.author | Passetti, Fabio | - |
dc.date.accessioned | 2023-03-08T23:52:01Z | - |
dc.date.available | 2023-03-08T23:52:01Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | POUBEL, Saloê BispO. Dysregulation of Transcription Factor Networks Unveils Different Pathways in Human Papillomavirus 16-Positive Squamous Cell Carcinoma and Adenocarcinoma of the Uterine Cervix. Frontiers In Oncology, [S.L.], v. 11, maio 2021. DOI: http://dx.doi.org/10.3389/fonc.2021.626187. | pt_BR |
dc.identifier.issn | 2234-943X | - |
dc.identifier.uri | https://ninho.inca.gov.br/jspui/handle/123456789/12982 | - |
dc.description | v. 11, 2021 | pt_BR |
dc.description.abstract | Squamous cell carcinoma (SCC) and adenocarcinoma (ADC) are the most common histological types of cervical cancer (CC). The worse prognosis of ADC cases highlights the need for better molecular characterization regarding differences between these CC types. RNA-Seq analysis of seven SCC and three ADC human papillomavirus 16-positive samples and the comparison with public data from non-tumoral human papillomavirus-negative cervical tissue samples revealed pathways exclusive to each histological type, such as the epithelial maintenance in SCC and the maturity-onset diabetes of the young (MODY) pathway in ADC. The transcriptional regulatory network analysis of cervical SCC samples unveiled a set of six transcription factor (TF) genes with the potential to positively regulate long non-coding RNA genes DSG1-AS1, CALML3-AS1, IGFL2-AS1, and TINCR. Additional analysis revealed a set of MODY TFs regulated in the sequence predicted to be repressed by miR-96-5p or miR-28-3p in ADC. These microRNAs were previously described to target LINC02381, which was predicted to be positively regulated by two MODY TFs upregulated in cervical ADC. Therefore, we hypothesize LINC02381 might act by decreasing the levels of miR-96-5p and miR-28-3p, promoting the MODY activation in cervical ADC. The novel TF networks here described should be explored for the development of more efficient diagnostic tools. | pt_BR |
dc.language.iso | eng | pt_BR |
dc.publisher | Frontiers in Oncology | pt_BR |
dc.relation.ispartofseries | v. 11; | - |
dc.subject | RNA-Seq | pt_BR |
dc.subject | Carcinoma de Células Escamosas | pt_BR |
dc.subject | Carcinoma, Squamous Cell | pt_BR |
dc.subject | Carcinoma de Células Escamosas | pt_BR |
dc.subject | Adenocarcinoma | pt_BR |
dc.subject | Papillomavirus Humano 16 | pt_BR |
dc.subject | Human papillomavirus 16 | pt_BR |
dc.title | Dysregulation of Transcription Factor Networks Unveils Different Pathways in Human Papillomavirus 16-Positive Squamous Cell Carcinoma and Adenocarcinoma of the Uterine Cervix | pt_BR |
dc.Type | Article | pt_BR |
dc.contributor.affilliation | Instituto Carlos Chagas, FIOCRUZ, Curitiba, Brazil. | pt_BR |
dc.contributor.affilliation | Department of Immunobiology, Biology Institute, Universidade Federal Fluminense (UFF), Niterói, Brazil. | pt_BR |
dc.contributor.affilliation | Laboratory of Immunogenetics and Histocompatibility, Department of Genetics, Universidade Federal do Paraná, Curitiba, Brazil. | pt_BR |
dc.contributor.affilliation | Department of Biochemistry, Instituto de Quimica, Universidade de São Paulo, São Paulo, Brazil. | pt_BR |
dc.contributor.affilliation | Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil. | pt_BR |
dc.contributor.affilliation | Bioinformatics Group, Department of Computer Science, Interdisciplinary Center for Bioinformatics, Leipzig University, Leipzig, Germany. | pt_BR |
dc.contributor.affilliation | Bioinformatics and Systems Biology Laboratory, Federal University of Paraná, Curitiba, Brazil. | pt_BR |
dc.contributor.affilliation | Atlantic Cancer Research Institute, Moncton, NB, Canada. | pt_BR |
dc.contributor.affilliation | Laboratory of Bioinformatics and Computational Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil. | pt_BR |
dc.contributor.affilliation | Discipline of Gynecology, Department of Obstetrics and Gynecology, Instituto do Cancer do Estado de São Paulo, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. | pt_BR |
dc.contributor.affilliation | Department of Radiology and Oncology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. | pt_BR |
dc.contributor.affilliation | Center for Translational Research in Oncology, Instituto do Cancer do Estado de São Paulo ICESP, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo FMUSP HC, São Paulo, Brazil. | pt_BR |
Appears in Collections: | Artigos de Periódicos da Pesquisa Experimental e Translacional |
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