Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/13900
Title: Cytogenetic as an Important Tool for Diagnosis and Prognosis for Patients with Hypocellular Primary Myelodysplastic Syndrome
Authors: Souza, Daiane Corrêa de Souza e
Fernandez, Cecília de Souza
Camargo, Adriana
Apa, Alexandre Gustavo
Costa, Elaine Sobral da
Bouzas, Luis Fernando da Silva
Abdelhay, Eliana Saul Furquim Werneck
Fernandez, Teresa de Souza
Keywords: Citogenética
Cytogenetics
Diagnóstico
Diagnosis
Prognóstico
Prognosis
Síndromes Mielodisplásicas
Myelodysplastic Syndromes
Issue Date: 2014
Abstract: We analyzed cytogenetically 105 patients with hypocellular primary MDS and their clinical implications. The main chromosomal abnormalities found were del(5q)/−5, del(6q)/+6, del(7q)/−7, del(11q), and del(17p). Pediatric patients had a higher frequency of abnormal karyotypes compared with adult patients (𝑃 < 0,05). From our patients, 18% showed evolution of the disease. The chromosomal abnormalities presented in the diagnosis of patients who evolved to AML included numerical (−7, +8) and structural del(6q), del(7q), i(7q), t(7;9), i(9q), and del(11q) abnormalities and complex karyotypes. Although the frequency of evolution from hypocellular MDS to AML is low, our results suggest that some chromosomal alterations may play a critical role during this process. We applied the IPSS in our patients because this score system has been proved to be useful for predicting evolution of disease. When we considered the patients according to group 1 (intermediate-1) and group 2 (intermediate-2 and high risk), we showed that group 2 had a high association with respect to the frequency of abnormal karyotypes (𝑃 < 0,0001), evolution of disease (𝑃 < 0,0001), and mortality (𝑃 < 0,001). In fact, the cytogenetic analysis for patients with hypocellular primary MDS is an important tool for diagnosis, prognosis, in clinical decision-making and in follow-up.
URI: https://ninho.inca.gov.br/jspui/handle/123456789/13900
ISSN: 2314-6141
Appears in Collections:Hospital do Câncer I (HCI)



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