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https://ninho.inca.gov.br/jspui/handle/123456789/13939| Title: | Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: Report of a new case and review of the literature |
| Authors: | Otero, Luize Souza, Daiane Corrêa de Souza e Tavares, Rita de Cássia Barbosa da Silva Gomes, Bernadete Evangelho Padilha, Telma de França Bouzas, Luis Fernando da Silva Fernandez, Teresa de Souza Abdelhay, Eliana Saul Furquim Werneck |
| Keywords: | Monossomia Monosomy Doadores de Tecidos Tissue Donors Leucemia de Células T Leukemia T-Cell Transplante de Medula Óssea Bone Marrow Transplantation Anemia Aplástica Anemia Aplastic Doença Catastrófica Catastrophic Illness |
| Issue Date: | Dec-2012 |
| Abstract: | Monosomy 7 arises as a recurrent chromosome aberration in donor cell leukemia after hematopoietic stem cell transplantation. We report a new case of donor cell leukemia with monosomy 7 following HLA-identical allogenic bone marrow transplantation for severe aplastic anemia (SAA). The male patient received a bone marrow graft from his sister, and monosomy 7 was detected only in the XX donor cells, 34 months after transplantation. The patient's bone marrow microenvironment may have played a role in the leukemic transformation of the donor hematopoietic cells. |
| URI: | https://ninho.inca.gov.br/jspui/handle/123456789/13939 |
| ISSN: | 1678-4685 |
| Appears in Collections: | Hospital do Câncer I (HCI) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia report of a new case and review of the literature. 2012..pdf | 638.37 kB | Adobe PDF | View/Open |
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