Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/13940
Title: Quantitative and qualitative differences in use and trends of hematopoietic stem cell transplantation: a Global Observational Study
Authors: Gratwohl, Alois
Baldomero, Helen
Gratwohl, Michael
Aljurf, Mahmoud
Bouzas, Luis Fernando da Silva
Horowitz, Mary
Kodera, Yoshihisa
Lipton, Jeff
Iida, Minako
Pasquini, Marcelo
Passweg, Jakob
Szer, Jeff
Madrigal, Alejandro
Frauendorfer, Karl
Niederwieser, Dietger
Keywords: Transplante de Células-Tronco Hematopoéticas
Hematopoietic Stem Cell Transplantation
Estudos de Avaliação como Assunto
Evaluation Studies as Topic
Estudo Observacional
Observational Study
Issue Date: Aug-2013
Abstract: Fifty-five years after publication of the first hematopoietic stem cell transplantation this technique has become an accepted treatment option for defined hematologic and non-hematologic disorders. There is considerable interest in understanding differences in its use and trends on a global level and the macro-economic factors associated with these differences. Data on the numbers of hematopoietic stem cell transplants performed in the 3-year period 2006-2008 were obtained from Worldwide Network for Blood and Marrow Transplantation member registries and from transplant centers in countries without registries. Population and macro-economic data were collected from the World Bank and from the International Monetary Fund. Transplant rates were analyzed by indication, donor type, country, and World Health Organization regional offices areas and related to selected health care indi cators using single and multiple linear regression analyses. Data from a total of 146,808 patients were reported by 1,411 teams from 72 countries over five continents. The annual number of transplants increased worldwide with the highest relative increase in the Asia Pacific region. Transplant rates increased preferentially in high income countries (P=0.02), not in low or medium income countries. Allogeneic transplants increased for myelodysplasia, chronic lymphocytic leukemia, acute leukemias, and non-malignant diseases but decreased for chronic myeloge nous leukemia. Autologous transplants increased for autoimmune and lymphoproliferative diseases but decreased for leukemias and solid tumors. Transplant rates (P<0.01), donor type (P<0.01) aand disease indications (P<0.01) differed significantly between countries and regions. Transplant rates were associated with Gross National Income/capita (P<0.01) but showed a wide variation of explanatory content by donor type, disease indication and World Health Organization region. Hematopoietic stem cell transplantation activity is increasing worldwide. The preferential increase in high income countries, the widening gap between low and high income countries and the significant regional differences suggest that different strategies are required in individual countries to foster hematopoietic stem cell transplantation as an efficient and cost-effective treatment modality
URI: https://ninho.inca.gov.br/jspui/handle/123456789/13940
ISSN: 1592-8721
Appears in Collections:Hospital do Câncer I (HCI)



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