Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/14458
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dc.contributor.authorMendes, Gélcio Luiz Quintella-
dc.contributor.authorRezende, Lidia Maria Magalhaes-
dc.contributor.authorRomano, Sergio de Oliveira-
dc.contributor.authorBigni, Ricardo de Sa-
dc.contributor.authorFaccion, Roberta Soares-
dc.contributor.authorMaia, Raquel Ciuvalschi-
dc.date.accessioned2023-07-21T18:05:46Z-
dc.date.available2023-07-21T18:05:46Z-
dc.date.issued2012-
dc.identifier.issn1532-4192-
dc.identifier.urihttps://ninho.inca.gov.br/jspui/handle/123456789/14458-
dc.description.abstractCentroblastic diffuse large B cell lymphoma (DLBCL) samples were analyzed by immunohistochemistry to evaluate the expression of p53, Bcl-2, Survivin, XIAP, and Ki-67. Survivin was the only protein which expression exhibited a trend for impact in progression-free (p = .077) and overall survival (p = .054). In the Mann-Whitney test, Survivin expression correlated with a negative overall survival (p = .045). These results appeared to be intimately related to Survivin cytoplasmic localization. Moreover, the anti-apoptotic proteins Bcl-2 and Survivin were less frequent in centroblastic DLBCL. Our results indicate that centroblastic DLBCL may be a disease with characteristic biology and clinical course and, therefore, specific prognostic factors.pt_BR
dc.subjectLinfoma Difuso de Grandes Células Bpt_BR
dc.subjectLymphoma Large B-Cell Diffusept_BR
dc.subjectGenes p53pt_BR
dc.subjectGenes bcl-2pt_BR
dc.subjectSurvivinapt_BR
dc.subjectSurvivinpt_BR
dc.subjectProteínas Inibidoras de Apoptose Ligadas ao Cromossomo Xpt_BR
dc.subjectX-Linked Inhibitor of Apoptosis Proteinpt_BR
dc.subjectAntígeno Ki-67pt_BR
dc.subjectKi-67 Antigenpt_BR
dc.subjectPrognósticopt_BR
dc.subjectPrognosispt_BR
dc.subjectImuno-Histoquímicapt_BR
dc.subjectImmunohistochemistrypt_BR
dc.titleCentroblastic Diffuse Large B Cell Lymphoma Displays Distinct Expression Pattern and Prognostic Role of Apoptosis Resistance Related Proteinspt_BR
dc.TypeArticlept_BR
Appears in Collections:Gélcio Luiz Quintella Mendes



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