Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/14458
Title: Centroblastic Diffuse Large B Cell Lymphoma Displays Distinct Expression Pattern and Prognostic Role of Apoptosis Resistance Related Proteins
Authors: Mendes, Gélcio Luiz Quintella
Rezende, Lidia Maria Magalhaes
Romano, Sergio de Oliveira
Bigni, Ricardo de Sa
Faccion, Roberta Soares
Maia, Raquel Ciuvalschi
Keywords: Linfoma Difuso de Grandes Células B
Lymphoma Large B-Cell Diffuse
Genes p53
Genes bcl-2
Survivina
Survivin
Proteínas Inibidoras de Apoptose Ligadas ao Cromossomo X
X-Linked Inhibitor of Apoptosis Protein
Antígeno Ki-67
Ki-67 Antigen
Prognóstico
Prognosis
Imuno-Histoquímica
Immunohistochemistry
Issue Date: 2012
Abstract: Centroblastic diffuse large B cell lymphoma (DLBCL) samples were analyzed by immunohistochemistry to evaluate the expression of p53, Bcl-2, Survivin, XIAP, and Ki-67. Survivin was the only protein which expression exhibited a trend for impact in progression-free (p = .077) and overall survival (p = .054). In the Mann-Whitney test, Survivin expression correlated with a negative overall survival (p = .045). These results appeared to be intimately related to Survivin cytoplasmic localization. Moreover, the anti-apoptotic proteins Bcl-2 and Survivin were less frequent in centroblastic DLBCL. Our results indicate that centroblastic DLBCL may be a disease with characteristic biology and clinical course and, therefore, specific prognostic factors.
URI: https://ninho.inca.gov.br/jspui/handle/123456789/14458
ISSN: 1532-4192
Appears in Collections:Gélcio Luiz Quintella Mendes



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