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https://ninho.inca.gov.br/jspui/handle/123456789/6311
Title: | Molecular and Clinical Profiles of Human Pegivirus Type 1 Infection in Individuals Living with HIV-1 in the Extreme South of Brazil |
Authors: | Mota, Luísa D. da Jardim, Fabiana Finger Silva, Cláudio M. Germano, Fabiana N. Nader, Maiba M. Gonçalves, Carla Vitola Chies, José A. B. Groll, Andrea V. Hora, Vanusa Pousada da Silveira, Jussara Basso, Rossana Patricia Soares, Marcelo Alves Martínez, Ana Maria Barral de Luquez, Karen Yumaira Sánchez |
Keywords: | CD4 Lymphocyte Count Coinfection/virology GB virus C/genetics HIV Infections/virology HIV-1/genetics |
Issue Date: | Jun-2019 |
Publisher: | BioMed Research International. |
Abstract: | Human pegivirus type 1 (HPgV-1) infection has been associated with a benefcial efect on the prognosis of human immunodef- ciency virus type 1 (HIV-1)-coinfected individuals. However, the mechanisms involved in this protection are not yet fully elucidated. To date, circulating HPgV-1 genotypes in HIV-1-infected individuals have not yet been identifed in the extreme south of Brazil. Te present study aimed to determine the genotypic circulation of HPgV-1 and the infuence of HPgV-1 status and persistence time on the evolution of HIV-1 infection. A retrospective cohort of 110 coinfected individuals was analyzed. Samples were subjected to viral RNA extraction, cDNA synthesis, nested PCR, and genotyping. Genotypes 1 (2.8%), 2 (47.9% of subtype 2a and 42.3% of subtype 2b), and 3 (7%) were identifed. In antiretroviral treatment-na ̈ıve subjects HPgV-1 subtype 2b was associated with lower HIV-1 viral load (VL) rates (p = 0.04) and higher CD4+ T-cell counts (p = 0.03) than was subtype 2a, and the positivity for HPgV-1 was associated with higher CD4+ T-cell counts (p = 0.02). However, there was no signifcant diference in HIV-1 VL between HPgV- 1-positive and HPgV-1-negative subjects (p = 0.08). Tere was no signifcant association between the diferent groups in HPgV-1 persistence and median HIV-1 VL (p = 0.66) or CD4+ T-cell counts (p = 0.15). HPgV-1 subtype 2b is associated with better prognosis of HIV-1 infection. Although HPgV-1 infection is persistent, our data suggest that the time of infection does not infuence HIV-1 VL or CD4+ T-cell counts in coinfected subjects. |
URI: | http://sr-vmlxaph03:8080/jspui/handle/123456789/6311 |
ISSN: | 2314-6141 |
Appears in Collections: | Artigos de Periódicos da Pesquisa Experimental e Translacional |
Files in This Item:
File | Description | Size | Format | |
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Molecular and Clinical Profiles of Human Pegivirus Type 1 Infection in Individuals Living with HIV-1 in the Extreme South of Brazil.pdf | 2.18 MB | Adobe PDF | View/Open |
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