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https://ninho.inca.gov.br/jspui/handle/123456789/7363
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DC Field | Value | Language |
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dc.contributor.author | Leal, Fabio Eudes | - |
dc.contributor.author | Mendes Corrêa, Maria Cássia Jacintho | - |
dc.contributor.author | Buss, Lewis Fletcher | - |
dc.contributor.author | Costa, Silvia Figueiredo | - |
dc.contributor.author | Bizário, João Carlos da Silva | - |
dc.contributor.author | Souza , Sonia Regina Pereira de | - |
dc.contributor.author | Thomaz, Osorio | - |
dc.contributor.author | Tozetto-Mendoza, Tania Regina | - |
dc.contributor.author | Boas, Lucy Santos Vilas | - |
dc.contributor.author | Silva, Léa Campos de Oliveira da | - |
dc.contributor.author | Grespan, Regina M. Z. | - |
dc.contributor.author | Capuani, Ligia | - |
dc.contributor.author | Buccheri, Renata | - |
dc.contributor.author | Domingues, Helves | - |
dc.contributor.author | Alexander, Neal | - |
dc.contributor.author | Mayaud, Philippe | - |
dc.contributor.author | Sabino, Ester Cerdeira | - |
dc.date.accessioned | 2022-06-09T20:16:11Z | - |
dc.date.available | 2022-06-09T20:16:11Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 2044-6055 | - |
dc.identifier.other | 10.1136/bmjopen-2020-042745 | - |
dc.identifier.uri | http://sr-vmlxaph03:8080/jspui/handle/123456789/7363 | - |
dc.description.abstract | Background Despite most cases not requiring hospital care, there are limited community-based clinical data on COVID-19. Methods The Corona São Caetano programme is a primary care initiative providing care to all residents with COVID-19 in São Caetano do Sul, Brazil. It was designed to capture standardised clinical data on community COVID-19 cases. After triage of potentially severe cases, consecutive patients presenting to a multimedia screening platform between 13 April and 13 May 2020 were tested at home with SARS-CoV-2 reverse transcriptase (RT) PCR; positive patients were followed up for 14 days with phone calls every 2 days. RT-PCR-negative patients were offered additional SARS-CoV-2 serology testing to establish their infection status. We describe the clinical, virological and natural history features of this prospective population- based cohort. Findings Of 2073 suspected COVID-19 cases, 1583 (76.4%) were tested by RT-PCR, of whom 444 (28.0%, 95%CI 25.9 to 30.3) were positive; 604/1136 (53%) RT- PCR-negative patients underwent serology, of whom 52 (8.6%) tested SARS-CoV-2 seropositive. The most common symptoms of confirmed COVID-19 were cough, fatigue, myalgia and headache; whereas self-reported fever (OR 3.0, 95%CI 2.4 to 3.9), anosmia (OR 3.3, 95%CI 2.6 to 4.4) and ageusia (OR 2.9, 95%CI 2.3 to 3.8) were most strongly associated with a positive COVID-19 diagnosis by RT-PCR or serology. RT-PCR cycle thresholds were lower in men, older patients, those with fever and arthralgia and closer to symptom onset. The rates of hospitalisation and death among 444 RT-PCR-positive cases were 6.7% and 0.7%, respectively, with older age and obesity more frequent in the hospitalised group. Conclusion COVID-19 presents in a similar way to other mild community-acquired respiratory diseases, but the presence of fever, anosmia and ageusia can assist the specific diagnosis. Most patients recovered without requiring hospitalisation with a low fatality rate compared with other hospital-based studies. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | BMJ Open | pt_BR |
dc.subject | Epidemiology | pt_BR |
dc.subject | Epidemiologia | pt_BR |
dc.subject | Epidemiología | pt_BR |
dc.subject | Communicable Diseases | pt_BR |
dc.subject | Doenças Transmissíveis | pt_BR |
dc.subject | Enfermedades Transmisibles | pt_BR |
dc.subject | Infectious Diseases | pt_BR |
dc.subject | Doenças Infecciosas | pt_BR |
dc.subject | Enfermedades Infecciosas | pt_BR |
dc.subject | Primary Health Care | pt_BR |
dc.subject | Atenção Primária à Saúde | pt_BR |
dc.subject | Atención Primaria de Salud | pt_BR |
dc.subject | Primary Care | pt_BR |
dc.subject | Public Health | pt_BR |
dc.subject | Saúde Pública | pt_BR |
dc.subject | Salud Pública | pt_BR |
dc.title | Clinical features and natural history of the first 2073 suspected COVID-19 cases in the Corona São Caetano primary care programme: a prospective cohort study | pt_BR |
dc.Type | Article | pt_BR |
Appears in Collections: | Artigos de Periódicos da Pesquisa Experimental e Translacional |
Files in This Item:
File | Description | Size | Format | |
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Clinical features and natural history of the first 2073 suspected COVID-19 cases in the Corona São Caetano primary care programme a prospective cohort study..pdf | 2.2 MB | Adobe PDF | View/Open |
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