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https://ninho.inca.gov.br/jspui/handle/123456789/8931| Title: | A comparative study of 131I and 177Lu labeled somatostatin analogues for therapy of neuroendocrine tumours |
| Authors: | Araújo, Elaine Bortoleti de Pujatti, Priscilla Brunelli Caldeira Filho, Jose de Souza Colturato, Maria Tereza Muramoto, Emiko Nagamati, Lúcio Takeshi Couto, Renata Martinussi Mengatti, Jair Silva, Christiano Pereira |
| Keywords: | Somatostatina Somatostatin Tumores Neuroendócrinos Neuroendocrine Tumors Tumores Neuroendocrinos Terapia Molecular Dirigida Terapia de Alvo Molecular Molecular Targeted Therapy |
| Issue Date: | 2009 |
| Publisher: | Applied Radiation and Isotopes |
| Citation: | ARAÚJO, Elaine Bortoleti de et al. A comparative study of 131I and 177Lu labeled somatostatin analogues for therapy of neuroendocrine tumours. Applied Radiation and Isotopes, v. 67, p. 227–233, 2009. |
| Abstract: | This work analysed the influence of the chelating group and radioligand on somatostatin analogues in vivo and in vitro properties. The presence of DOTA in the radioiodinated peptide produced a labeled analogue with similar blood kinetics and biodistribution to 177Lu-DOTATATE and with lower abdominal uptake than 131I-TATE. In addition, 131I-DOTATATE showed significative tumour uptake, despite not so persistent after 24 h. 131I-DOTATATE can represent a cost-effective alternative to lutetium labeled peptide for neuroendocrine tumours therapy. |
| Description: | p. 227–233.: il p&b. e color. |
| URI: | http://sr-vmlxaph03:8080/jspui/handle/123456789/8931 |
| Appears in Collections: | Artigos de Periódicos da área de Farmácia |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| A comparative study of 131I and 177Lu labeled somatostatin analogues for therapy of neuroendocrine tumours..pdf | 473.66 kB | Adobe PDF | View/Open |
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