Please use this identifier to cite or link to this item: https://ninho.inca.gov.br/jspui/handle/123456789/12199
Title: The role of interferon-γ on immune and allergic responses
Authors: Teixeira, Leonardo Augusto Karam
Fonseca, Bruna de Paula Fonseca e
Barboza, Bianca A.
Viola, Joao Paulo de Biaso
Keywords: Interferon gama
Interferon-gamma
Linfócitos
Lymphocytes
Sistema Imunitário
Immune System
Hipersensibilidade
Hypersensitivity
Inflamação
Inflammation
Issue Date: Mar-2005
Abstract: Allergic diseases have been closely related to Th2 immune responses, which are characterized by high levels of interleukin (IL) IL-4, IL-5, IL-9 and IL-13. These cytokines orchestrate the recruitment and activation of different effector cells, such as eosinophils and mast cells. These cells along with Th2 cytokines are key players on the development of chronic allergic inflammatory disorders, usually characterized by airway hyperresponsiveness, reversible airway obstruction, and airway inflammation. Accumulating evidences have shown that altering cytokine producing profile of Th2 cells by inducing Th1 responses may be protective against Th2-related diseases such as asthma and allergy. Interferon-γ (IFN-γ), the principal Th1 effector cytokine, has shown to be crucial for the resolu tion of allergic-related immunopathologies. In fact, reduced production of this cytokine has been correlated with severe asthma. In this review, we will discuss the role of IFN-γ during the generation of immune responses and its influence on allergic inflammation models, emphasizing its biologic properties during the different aspects of allergic responses.
URI: https://ninho.inca.gov.br/jspui/handle/123456789/12199
ISSN: 1678-8060
Appears in Collections:Artigos de Periódicos da Pesquisa Experimental e Translacional

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