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https://ninho.inca.gov.br/jspui/handle/123456789/14458| Title: | Centroblastic Diffuse Large B Cell Lymphoma Displays Distinct Expression Pattern and Prognostic Role of Apoptosis Resistance Related Proteins |
| Authors: | Mendes, Gelcio Luiz Quintella Rezende, Lidia Maria Magalhaes Romano, Sergio de Oliveira Bigni, Ricardo de Sa Faccion, Roberta Soares Maia, Raquel Ciuvalschi |
| Keywords: | Linfoma Difuso de Grandes Células B Lymphoma Large B-Cell Diffuse Genes p53 Genes bcl-2 Survivina Survivin Proteínas Inibidoras de Apoptose Ligadas ao Cromossomo X X-Linked Inhibitor of Apoptosis Protein Antígeno Ki-67 Ki-67 Antigen Prognóstico Prognosis Imuno-Histoquímica Immunohistochemistry |
| Issue Date: | 2012 |
| Abstract: | Centroblastic diffuse large B cell lymphoma (DLBCL) samples were analyzed by immunohistochemistry to evaluate the expression of p53, Bcl-2, Survivin, XIAP, and Ki-67. Survivin was the only protein which expression exhibited a trend for impact in progression-free (p = .077) and overall survival (p = .054). In the Mann-Whitney test, Survivin expression correlated with a negative overall survival (p = .045). These results appeared to be intimately related to Survivin cytoplasmic localization. Moreover, the anti-apoptotic proteins Bcl-2 and Survivin were less frequent in centroblastic DLBCL. Our results indicate that centroblastic DLBCL may be a disease with characteristic biology and clinical course and, therefore, specific prognostic factors. |
| URI: | https://ninho.inca.gov.br/jspui/handle/123456789/14458 |
| ISSN: | 1532-4192 |
| Appears in Collections: | Gélcio Luiz Quintella Mendes |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Centroblastic Diffuse Large B Cell Lymphoma Displays Distinct Expression Pattern and Prognostic Role....pdf | 781.83 kB | Adobe PDF | View/Open |
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