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https://ninho.inca.gov.br/jspui/handle/123456789/6908| Title: | Human Endogenous Retrovirus K in Cancer: A Potential Biomarker and Immunotherapeutic Target |
| Authors: | Curty, Gislaine Marston, Jez L. Mulder Rougvie, Miguel de Leal, Fabio Eudes Nixon, Douglas F. Soares, Marcelo Alves |
| Keywords: | Endogenous Retroviruses Retrovirus Endógenos HERV Carcinogenesis Carcinogênese Carcinogénesis Oncogenesis Oncogénesis Oncogênese Neoplasms Neoplasias Cancer Cáncer Câncer Immunity Imunidade Inmunidad Immune Response Resposta Imune Respuesta Inmune Immunotherapy Imunoterapia Inmunoterapia |
| Issue Date: | 2020 |
| Publisher: | Viruses |
| Abstract: | In diseases where epigenetic mechanisms are changed, such as cancer, many genes show altered gene expression and inhibited genes become activated. Human endogenous retrovirus type K (HERV-K) expression is usually inhibited in normal cells from healthy adults. In tumor cells, however, HERV-K mRNA expression has been frequently documented to increase. Importantly, HERV-K-derived proteins can act as tumor-specific antigens, a class of neoantigens, and induce immune responses in different types of cancer. In this review, we describe the function of the HERV-K HML-2 subtype in carcinogenesis as biomarkers, and their potential as targets for cancer immunotherapy. |
| URI: | http://sr-vmlxaph03:8080/jspui/handle/123456789/6908 |
| ISSN: | 1999-4915 |
| Appears in Collections: | Artigos de Periódicos da Pesquisa Experimental e Translacional |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Human Endogenous Retrovirus K in Cancer A Potential Biomarker and Immunotherapeutic Target.pdf | 760.3 kB | Adobe PDF | View/Open |
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